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Cytoplasmic HuR expression: Correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells

Authors
 Jeong-Dan Cha  ;  Hee-Kyeong Kim  ;  In-Ho Cha 
Citation
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.36(8) : 1168-1175, 2014 
Journal Title
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 
ISSN
 1043-3074 
Issue Date
2014
MeSH
Aged ; Baculoviral IAP Repeat-Containing 3 Protein ; Blotting, Western ; Carcinoma, Squamous Cell/metabolism* ; Carcinoma, Squamous Cell/mortality ; Cell Culture Techniques ; Cell Line, Tumor ; Cytoplasm/metabolism ; ELAV Proteins/metabolism* ; Female ; Humans ; Immunohistochemistry ; Inhibitor of Apoptosis Proteins/metabolism* ; Male ; Middle Aged ; Mouth Neoplasms/metabolism* ; Mouth Neoplasms/mortality ; Mouth Neoplasms/pathology ; Republic of Korea ; Reverse Transcriptase Polymerase Chain Reaction ; Survival Rate ; Transfection ; Ubiquitin-Protein Ligases
Keywords
HuR ; cellular inhibitors of apoptosis protein-2 (cIAP2) ; inhibitors of apoptosis proteins ; mRNA stability ; oral squamous cell carcinoma
Abstract
BACKGROUND: HuR expression has been noted in several cancer types, in which it may contribute to increased expression of cellular inhibitors of apoptosis protein-2 (cIAP2) observed during tumorigenesis. METHODS: To assess the correlation between cIAP2 and HuR in cases of oral squamous cell carcinoma (OSCC), the expression patterns of HuR and cIAP2 were assessed by immunohistochemical analyses of 95 treated OSCC samples. RESULTS: In the tumor tissues, positive cytoplasmic HuR expression was evident in 71.6% of samples and positive cIAP2 expression was noted in 95.8% of samples. Positive cytoplasmic HuR expression was significantly associated with positive cIAP2 (p < .035) and high cIAP2 expression (p < .007), as well as high grade (p < .050). The inhibition of HuR expression by small interfering RNA or leptomycin B caused a reduction in the inducibility of cIAP2 in oral cancer cells. CONCLUSION: Cytoplasmic expression of HuR is associated with cIAP2 expression in OSCCs.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.23431/abstract
DOI
10.1002/hed.23431
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
Yonsei Authors
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
Cha, Jeong Dan(차정단)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99468
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