Cited 13 times in
Cytoplasmic HuR expression: Correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells
DC Field | Value | Language |
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dc.contributor.author | 차인호 | - |
dc.contributor.author | 차정단 | - |
dc.date.accessioned | 2015-01-06T17:10:18Z | - |
dc.date.available | 2015-01-06T17:10:18Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99468 | - |
dc.description.abstract | BACKGROUND: HuR expression has been noted in several cancer types, in which it may contribute to increased expression of cellular inhibitors of apoptosis protein-2 (cIAP2) observed during tumorigenesis. METHODS: To assess the correlation between cIAP2 and HuR in cases of oral squamous cell carcinoma (OSCC), the expression patterns of HuR and cIAP2 were assessed by immunohistochemical analyses of 95 treated OSCC samples. RESULTS: In the tumor tissues, positive cytoplasmic HuR expression was evident in 71.6% of samples and positive cIAP2 expression was noted in 95.8% of samples. Positive cytoplasmic HuR expression was significantly associated with positive cIAP2 (p < .035) and high cIAP2 expression (p < .007), as well as high grade (p < .050). The inhibition of HuR expression by small interfering RNA or leptomycin B caused a reduction in the inducibility of cIAP2 in oral cancer cells. CONCLUSION: Cytoplasmic expression of HuR is associated with cIAP2 expression in OSCCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1168~1175 | - |
dc.relation.isPartOf | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Baculoviral IAP Repeat-Containing 3 Protein | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Carcinoma, Squamous Cell/metabolism* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/mortality | - |
dc.subject.MESH | Cell Culture Techniques | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cytoplasm/metabolism | - |
dc.subject.MESH | ELAV Proteins/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Inhibitor of Apoptosis Proteins/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mouth Neoplasms/metabolism* | - |
dc.subject.MESH | Mouth Neoplasms/mortality | - |
dc.subject.MESH | Mouth Neoplasms/pathology | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Transfection | - |
dc.subject.MESH | Ubiquitin-Protein Ligases | - |
dc.title | Cytoplasmic HuR expression: Correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral and Maxillofacial Surgery (구강악안면외과학) | - |
dc.contributor.googleauthor | Jeong-Dan Cha | - |
dc.contributor.googleauthor | Hee-Kyeong Kim | - |
dc.contributor.googleauthor | In-Ho Cha | - |
dc.identifier.doi | 10.1002/hed.23431 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04005 | - |
dc.contributor.localId | A04002 | - |
dc.relation.journalcode | J00963 | - |
dc.identifier.eissn | 1097-0347 | - |
dc.identifier.pmid | 23852810 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/hed.23431/abstract | - |
dc.subject.keyword | HuR | - |
dc.subject.keyword | cellular inhibitors of apoptosis protein-2 (cIAP2) | - |
dc.subject.keyword | inhibitors of apoptosis proteins | - |
dc.subject.keyword | mRNA stability | - |
dc.subject.keyword | oral squamous cell carcinoma | - |
dc.contributor.alternativeName | Cha, In Ho | - |
dc.contributor.alternativeName | Cha, Jeong Dan | - |
dc.contributor.affiliatedAuthor | Cha, Jeong Dan | - |
dc.contributor.affiliatedAuthor | Cha, In Ho | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 36 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1168 | - |
dc.citation.endPage | 1175 | - |
dc.identifier.bibliographicCitation | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.36(8) : 1168-1175, 2014 | - |
dc.identifier.rimsid | 39444 | - |
dc.type.rims | ART | - |
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