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Expression of Autophagy-Related Proteins According to Androgen Receptor and HER-2 Status in Estrogen Receptor-Negative Breast Cancer.

Authors
 Ji-Ye Kim  ;  Woo Hee Jung  ;  Ja Seung Koo 
Citation
 PLOS ONE, Vol.9(8) : e105666, 2014 
Journal Title
 PLOS ONE 
Issue Date
2014
MeSH
Adult ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism* ; Autophagy/genetics* ; Beclin-1 ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology ; Female ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism* ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism* ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism* ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism* ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism*
Abstract
PURPOSE: The purpose of this study was to investigate the expression of autophagy-related proteins in relation to androgen receptor (AR) status in estrogen receptor (ER)-negative breast cancers. METHODS: We extracted 334 ER-negative breast cancer samples to construct tissue microarrays (TMAs), which were immunohistochemically stained for autophagy-related proteins (beclin-1, LC3A, LC3B, p62) and for AR and HER-2. RESULTS: There were 127 AR-positive cases and 207 AR-negative cases, and 140 HER-2-positive cases and 194 HER-2 negative cases. The AR-negative group was associated with tumoral LC3A expression (P<0.001), while the AR-positive group was associated with tumoral BNIP3 expression (P<0.001). Tumoral LC3A was most highly expressed in the AR-negative and HER-2 negative group, while stromal LC3A showed the highest expression in the AR-negative and HER-2-positive group. Tumoral BNIP3 and stromal BNIP3 were highest in the AR-positive and HER-2-negative group. In the AR-positive and HER-2-negative group, stromal p62 positivity was an independent factor that was statistically significant in its association with shorter disease-free survival (DFS) (Hazard ratio: 10.21, 95% CI: 1.130-92.31, P = 0.039). Shorter DFS was associated with tumoral LC3A positivity (Hazard ratio: 10.28, 95% CI: 2.068-51.19, P = 0.004) in the AR-negative and HER-2-positive group. CONCLUSION: In ER-negative breast cancers, AR status was associated with expression of different types of autophagy-related proteins. Tumoral LC3A was most highly expressed in AR-negative breast cancers, while tumor BNIP3 was highest in AR-positive breast cancers.
Files in This Item:
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DOI
10.1371/journal.pone.0105666
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Jung, Woo Hee(정우희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99410
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