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Cited 12 times in

Expression of Autophagy-Related Proteins According to Androgen Receptor and HER-2 Status in Estrogen Receptor-Negative Breast Cancer.

DC Field Value Language
dc.contributor.author구자승-
dc.contributor.author정우희-
dc.date.accessioned2015-01-06T17:08:19Z-
dc.date.available2015-01-06T17:08:19Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99410-
dc.description.abstractPURPOSE: The purpose of this study was to investigate the expression of autophagy-related proteins in relation to androgen receptor (AR) status in estrogen receptor (ER)-negative breast cancers. METHODS: We extracted 334 ER-negative breast cancer samples to construct tissue microarrays (TMAs), which were immunohistochemically stained for autophagy-related proteins (beclin-1, LC3A, LC3B, p62) and for AR and HER-2. RESULTS: There were 127 AR-positive cases and 207 AR-negative cases, and 140 HER-2-positive cases and 194 HER-2 negative cases. The AR-negative group was associated with tumoral LC3A expression (P<0.001), while the AR-positive group was associated with tumoral BNIP3 expression (P<0.001). Tumoral LC3A was most highly expressed in the AR-negative and HER-2 negative group, while stromal LC3A showed the highest expression in the AR-negative and HER-2-positive group. Tumoral BNIP3 and stromal BNIP3 were highest in the AR-positive and HER-2-negative group. In the AR-positive and HER-2-negative group, stromal p62 positivity was an independent factor that was statistically significant in its association with shorter disease-free survival (DFS) (Hazard ratio: 10.21, 95% CI: 1.130-92.31, P = 0.039). Shorter DFS was associated with tumoral LC3A positivity (Hazard ratio: 10.28, 95% CI: 2.068-51.19, P = 0.004) in the AR-negative and HER-2-positive group. CONCLUSION: In ER-negative breast cancers, AR status was associated with expression of different types of autophagy-related proteins. Tumoral LC3A was most highly expressed in AR-negative breast cancers, while tumor BNIP3 was highest in AR-positive breast cancers.-
dc.description.statementOfResponsibilityopen-
dc.format.extente105666-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHApoptosis Regulatory Proteins/genetics-
dc.subject.MESHApoptosis Regulatory Proteins/metabolism*-
dc.subject.MESHAutophagy/genetics*-
dc.subject.MESHBeclin-1-
dc.subject.MESHBreast Neoplasms/metabolism*-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMembrane Proteins/genetics-
dc.subject.MESHMembrane Proteins/metabolism*-
dc.subject.MESHMicrotubule-Associated Proteins/genetics-
dc.subject.MESHMicrotubule-Associated Proteins/metabolism*-
dc.subject.MESHProto-Oncogene Proteins/genetics-
dc.subject.MESHProto-Oncogene Proteins/metabolism*-
dc.subject.MESHProto-Oncogene Proteins c-myc/genetics-
dc.subject.MESHProto-Oncogene Proteins c-myc/metabolism-
dc.subject.MESHReceptor, ErbB-2/genetics-
dc.subject.MESHReceptor, ErbB-2/metabolism*-
dc.subject.MESHReceptors, Androgen/genetics-
dc.subject.MESHReceptors, Androgen/metabolism*-
dc.titleExpression of Autophagy-Related Proteins According to Androgen Receptor and HER-2 Status in Estrogen Receptor-Negative Breast Cancer.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorJi-Ye Kim-
dc.contributor.googleauthorWoo Hee Jung-
dc.contributor.googleauthorJa Seung Koo-
dc.identifier.doi10.1371/journal.pone.0105666-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA03671-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid25140630-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume9-
dc.citation.number8-
dc.citation.startPagee105666-
dc.identifier.bibliographicCitationPLOS ONE, Vol.9(8) : e105666, 2014-
dc.identifier.rimsid57251-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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