Cited 12 times in
Expression of Autophagy-Related Proteins According to Androgen Receptor and HER-2 Status in Estrogen Receptor-Negative Breast Cancer.
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2015-01-06T17:08:19Z | - |
dc.date.available | 2015-01-06T17:08:19Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99410 | - |
dc.description.abstract | PURPOSE: The purpose of this study was to investigate the expression of autophagy-related proteins in relation to androgen receptor (AR) status in estrogen receptor (ER)-negative breast cancers. METHODS: We extracted 334 ER-negative breast cancer samples to construct tissue microarrays (TMAs), which were immunohistochemically stained for autophagy-related proteins (beclin-1, LC3A, LC3B, p62) and for AR and HER-2. RESULTS: There were 127 AR-positive cases and 207 AR-negative cases, and 140 HER-2-positive cases and 194 HER-2 negative cases. The AR-negative group was associated with tumoral LC3A expression (P<0.001), while the AR-positive group was associated with tumoral BNIP3 expression (P<0.001). Tumoral LC3A was most highly expressed in the AR-negative and HER-2 negative group, while stromal LC3A showed the highest expression in the AR-negative and HER-2-positive group. Tumoral BNIP3 and stromal BNIP3 were highest in the AR-positive and HER-2-negative group. In the AR-positive and HER-2-negative group, stromal p62 positivity was an independent factor that was statistically significant in its association with shorter disease-free survival (DFS) (Hazard ratio: 10.21, 95% CI: 1.130-92.31, P = 0.039). Shorter DFS was associated with tumoral LC3A positivity (Hazard ratio: 10.28, 95% CI: 2.068-51.19, P = 0.004) in the AR-negative and HER-2-positive group. CONCLUSION: In ER-negative breast cancers, AR status was associated with expression of different types of autophagy-related proteins. Tumoral LC3A was most highly expressed in AR-negative breast cancers, while tumor BNIP3 was highest in AR-positive breast cancers. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e105666 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Apoptosis Regulatory Proteins/genetics | - |
dc.subject.MESH | Apoptosis Regulatory Proteins/metabolism* | - |
dc.subject.MESH | Autophagy/genetics* | - |
dc.subject.MESH | Beclin-1 | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Membrane Proteins/genetics | - |
dc.subject.MESH | Membrane Proteins/metabolism* | - |
dc.subject.MESH | Microtubule-Associated Proteins/genetics | - |
dc.subject.MESH | Microtubule-Associated Proteins/metabolism* | - |
dc.subject.MESH | Proto-Oncogene Proteins/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins/metabolism* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/metabolism | - |
dc.subject.MESH | Receptor, ErbB-2/genetics | - |
dc.subject.MESH | Receptor, ErbB-2/metabolism* | - |
dc.subject.MESH | Receptors, Androgen/genetics | - |
dc.subject.MESH | Receptors, Androgen/metabolism* | - |
dc.title | Expression of Autophagy-Related Proteins According to Androgen Receptor and HER-2 Status in Estrogen Receptor-Negative Breast Cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Ji-Ye Kim | - |
dc.contributor.googleauthor | Woo Hee Jung | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1371/journal.pone.0105666 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 25140630 | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | e105666 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.9(8) : e105666, 2014 | - |
dc.identifier.rimsid | 57251 | - |
dc.type.rims | ART | - |
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