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Effect of Androsterone after Pilocarpine-induced Status Epilepticus in Mice
DC Field | Value | Language |
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dc.contributor.author | 김원주 | - |
dc.contributor.author | 김현우 | - |
dc.contributor.author | 이병인 | - |
dc.contributor.author | 조양제 | - |
dc.contributor.author | 조인자 | - |
dc.contributor.author | 허경 | - |
dc.date.accessioned | 2015-01-06T17:06:30Z | - |
dc.date.available | 2015-01-06T17:06:30Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2233-6249 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99359 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: Neurosteroids exert their antiepileptic effects via GABAA and NMDA receptors. Another cell death mechanism is excessive Ca(2+) influx into cells. Calbindin-D28k (CB) is a protein that modulates intracellular Ca(2+) in the nervous system. We evaluated whether androsterone up-regulates the expression of CB and has a neuroprotective effect by controlling Ca(2+) after pilocarpine-induced status epilepticus (SE) in mice. METHODS: SE was induced in ICR mice by injection of pilocarpine. Two hours after SE, mice were treated intraperitoneally (i.p.) with androsterone (100-200 mg/kg) or vehicle, and compared with other control groups. Two days after injection, immunohistochemical staining for CB was performed using a hippocampal slice from each mice group. We also used cresyl violet staining to compare changes in hippocampal structures. RESULTS: Two days after pilocarpine-induced SE, androsterone increased the expression of CB in the hippocampus compared with control SE mice. The number of CB-positive cells was 1±0.4 cells/mm(3) in pilocarpine-only group, 14±1.1 cells/mm(3) in pilocarpine plus androsterone 100 mg group and 29±2.5 cells/mm(3) in pilocarpine plus androsterone 200 mg group (p<0.001). CONCLUSIONS: These results suggest that the neuroprotective effect of androsterone after pilocarpine- induced SE may be mediated by an increased expression of CB. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 7~13 | - |
dc.relation.isPartOf | Journal of Epilepsy Research | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of Androsterone after Pilocarpine-induced Status Epilepticus in Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Inja Cho | - |
dc.contributor.googleauthor | Yang-Je Cho | - |
dc.contributor.googleauthor | Hyun-Woo Kim | - |
dc.contributor.googleauthor | Kyung Heo | - |
dc.contributor.googleauthor | Byung-In Lee | - |
dc.contributor.googleauthor | Won-Joo Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00771 | - |
dc.contributor.localId | A02797 | - |
dc.contributor.localId | A03851 | - |
dc.contributor.localId | A03891 | - |
dc.contributor.localId | A04341 | - |
dc.contributor.localId | A01125 | - |
dc.relation.journalcode | J01404 | - |
dc.identifier.pmid | 24977124 | - |
dc.subject.keyword | Androsterone | - |
dc.subject.keyword | Calbindin-D28k | - |
dc.subject.keyword | Hippocampus | - |
dc.subject.keyword | Neurosteroid | - |
dc.subject.keyword | Seizure | - |
dc.contributor.alternativeName | Kim, Won Joo | - |
dc.contributor.alternativeName | Kim, Hyun Woo | - |
dc.contributor.alternativeName | Lee, Byung In | - |
dc.contributor.alternativeName | Cho, Yang Je | - |
dc.contributor.alternativeName | Cho, In Ja | - |
dc.contributor.alternativeName | Heo, Kyoung | - |
dc.contributor.affiliatedAuthor | Kim, Won Joo | - |
dc.contributor.affiliatedAuthor | Lee, Byung In | - |
dc.contributor.affiliatedAuthor | Cho, Yang Je | - |
dc.contributor.affiliatedAuthor | Cho, In Ja | - |
dc.contributor.affiliatedAuthor | Heo, Kyoung | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Woo | - |
dc.citation.volume | 4 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 7 | - |
dc.citation.endPage | 13 | - |
dc.identifier.bibliographicCitation | Journal of Epilepsy Research, Vol.4(1) : 7-13, 2014 | - |
dc.identifier.rimsid | 57214 | - |
dc.type.rims | ART | - |
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