0 264

Cited 43 times in

Anesthetics influence the incidence of acute kidney injury following valvular heart surgery

 Young-Chul Yoo  ;  Jae-Kwang Shim  ;  Young Song  ;  So-Young Yang  ;  Young-Lan Kwak 
 KIDNEY INTERNATIONAL, Vol.86(2) : 414-422, 2014 
Journal Title
Issue Date
Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology* ; Acute Kidney Injury/prevention & control* ; Aged ; Anesthetics, General/adverse effects* ; Anesthetics, General/therapeutic use* ; Anesthetics, Inhalation/adverse effects ; Anesthetics, Inhalation/therapeutic use ; Anesthetics, Intravenous/adverse effects ; Anesthetics, Intravenous/therapeutic use ; Cardiac Surgical Procedures/adverse effects* ; Cardiopulmonary Bypass/adverse effects ; Female ; Heart Valve Diseases/surgery* ; Humans ; Incidence ; Male ; Methyl Ethers/adverse effects ; Methyl Ethers/therapeutic use ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Propofol/adverse effects ; Propofol/therapeutic use ; Prospective Studies ; Republic of Korea/epidemiology ; Sufentanil/adverse effects ; Sufentanil/therapeutic use
acute kidney injury ; cardiac surgery ; cardiopulmonary bypass ; inflammation ; ischemia–reperfusion ; propofol
Propofol has been shown to provide protection against renal ischemia/reperfusion injury experimentally, but clinical evidence is lacking. Here we studied the effect of propofol anesthesia on the occurrence of acute kidney injury following heart surgery with cardiopulmonary bypass. One hundred and twelve patients who underwent valvular heart surgery were randomized to receive either propofol or sevoflurane anesthesia, both with sufentanil. Using Acute Kidney Injury Network criteria, significantly fewer patients developed acute kidney injury postoperatively in the propofol group compared with the sevoflurane group (6 compared with 21 patients). The incidence of severe renal dysfunction was significantly higher in the sevoflurane group compared with the propofol group (5 compared with none). The postoperative cystatin C was significantly lower in the propofol group at 24 and 48 h. Serum interleukin-6 at 6 h after aorta cross-clamp removal, C-reactive protein at postoperative day 1, and segmented neutrophil counts at postoperative day 3 were also significantly lower in the propofol group. Thus, propofol anesthesia significantly reduced the incidence and severity of acute kidney injury in patients undergoing valvular heart surgery with cardiopulmonary bypass compared with sevoflurane. This beneficial effect of propofol may be related to its ability to attenuate the perioperative increase in proinflammatory mediators.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Song, Young(송영) ORCID logo https://orcid.org/0000-0003-4597-387X
Shim, Jae Kwang(심재광) ORCID logo https://orcid.org/0000-0001-9093-9692
Yang, So Young(양소영)
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.