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Anesthetics influence the incidence of acute kidney injury following valvular heart surgery

DC FieldValueLanguage
dc.contributor.author곽영란-
dc.contributor.author송영-
dc.contributor.author심재광-
dc.contributor.author양소영-
dc.contributor.author유영철-
dc.date.accessioned2015-01-06T17:06:16Z-
dc.date.available2015-01-06T17:06:16Z-
dc.date.issued2014-
dc.identifier.issn0085-2538-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99353-
dc.description.abstractPropofol has been shown to provide protection against renal ischemia/reperfusion injury experimentally, but clinical evidence is lacking. Here we studied the effect of propofol anesthesia on the occurrence of acute kidney injury following heart surgery with cardiopulmonary bypass. One hundred and twelve patients who underwent valvular heart surgery were randomized to receive either propofol or sevoflurane anesthesia, both with sufentanil. Using Acute Kidney Injury Network criteria, significantly fewer patients developed acute kidney injury postoperatively in the propofol group compared with the sevoflurane group (6 compared with 21 patients). The incidence of severe renal dysfunction was significantly higher in the sevoflurane group compared with the propofol group (5 compared with none). The postoperative cystatin C was significantly lower in the propofol group at 24 and 48 h. Serum interleukin-6 at 6 h after aorta cross-clamp removal, C-reactive protein at postoperative day 1, and segmented neutrophil counts at postoperative day 3 were also significantly lower in the propofol group. Thus, propofol anesthesia significantly reduced the incidence and severity of acute kidney injury in patients undergoing valvular heart surgery with cardiopulmonary bypass compared with sevoflurane. This beneficial effect of propofol may be related to its ability to attenuate the perioperative increase in proinflammatory mediators.-
dc.description.statementOfResponsibilityopen-
dc.format.extent414~422-
dc.relation.isPartOfKIDNEY INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Kidney Injury/epidemiology-
dc.subject.MESHAcute Kidney Injury/etiology*-
dc.subject.MESHAcute Kidney Injury/prevention & control*-
dc.subject.MESHAged-
dc.subject.MESHAnesthetics, General/adverse effects*-
dc.subject.MESHAnesthetics, General/therapeutic use*-
dc.subject.MESHAnesthetics, Inhalation/adverse effects-
dc.subject.MESHAnesthetics, Inhalation/therapeutic use-
dc.subject.MESHAnesthetics, Intravenous/adverse effects-
dc.subject.MESHAnesthetics, Intravenous/therapeutic use-
dc.subject.MESHCardiac Surgical Procedures/adverse effects*-
dc.subject.MESHCardiopulmonary Bypass/adverse effects-
dc.subject.MESHFemale-
dc.subject.MESHHeart Valve Diseases/surgery*-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMethyl Ethers/adverse effects-
dc.subject.MESHMethyl Ethers/therapeutic use-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPostoperative Complications/epidemiology-
dc.subject.MESHPostoperative Complications/etiology-
dc.subject.MESHPostoperative Complications/prevention & control-
dc.subject.MESHPropofol/adverse effects-
dc.subject.MESHPropofol/therapeutic use-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSufentanil/adverse effects-
dc.subject.MESHSufentanil/therapeutic use-
dc.titleAnesthetics influence the incidence of acute kidney injury following valvular heart surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorYoung-Chul Yoo-
dc.contributor.googleauthorJae-Kwang Shim-
dc.contributor.googleauthorYoung Song-
dc.contributor.googleauthorSo-Young Yang-
dc.contributor.googleauthorYoung-Lan Kwak-
dc.identifier.doi10.1038/ki.2013.532-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00172-
dc.contributor.localIdA02036-
dc.contributor.localIdA02205-
dc.contributor.localIdA02291-
dc.contributor.localIdA02484-
dc.relation.journalcodeJ01941-
dc.identifier.eissn1523-1755-
dc.identifier.pmid24429400-
dc.identifier.urlhttp://www.nature.com/ki/journal/v86/n2/full/ki2013532a.html-
dc.subject.keywordacute kidney injury-
dc.subject.keywordcardiac surgery-
dc.subject.keywordcardiopulmonary bypass-
dc.subject.keywordinflammation-
dc.subject.keywordischemia–reperfusion-
dc.subject.keywordpropofol-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameSong, Young-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameYang, So Young-
dc.contributor.alternativeNameYoo, Young Chul-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorSong, Young-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorYang, So Young-
dc.contributor.affiliatedAuthorYoo, Young Chul-
dc.rights.accessRightsfree-
dc.citation.volume86-
dc.citation.number2-
dc.citation.startPage414-
dc.citation.endPage422-
dc.identifier.bibliographicCitationKIDNEY INTERNATIONAL, Vol.86(2) : 414-422, 2014-
dc.identifier.rimsid57209-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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