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Follow-up outcomes of endoscopic resection for early gastric cancer with undifferentiated histology

Authors
 Jie-Hyun Kim  ;  Yong Hoon Kim  ;  Da Hyun Jung  ;  Han Ho Jeon  ;  Yong Chan Lee  ;  Hyuk Lee  ;  Sang Kil Lee  ;  Jun Chul Park  ;  Sung Kwan Shin  ;  Young Hoon Youn  ;  Hyojin Park 
Citation
 SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol.28(9) : 2627-2633, 2014 
Journal Title
 SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 
ISSN
 0930-2794 
Issue Date
2014
MeSH
Adenocarcinoma/pathology ; Adenocarcinoma/surgery* ; Carcinoma, Signet Ring Cell/pathology ; Carcinoma, Signet Ring Cell/surgery* ; Disease-Free Survival ; Endoscopy/methods ; Follow-Up Studies ; Gastroscopy/methods* ; Humans ; Neoplasm Recurrence, Local ; Retrospective Studies ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery* ; Survival Rate ; Time Factors ; Treatment Outcome
Keywords
Early gastric cancer ; Undifferentiated ; Endoscopic resection ; Survival ; Recurrence
Abstract
BACKGROUND:The application of endoscopic resection (ER) for undifferentiated-type early gastric cancer (UD-EGC) remains controversial. The aim was to examine long-term outcomes of ER for UD-EGC. Furthermore, we investigated whether long-term outcomes of ER differed between poorly differentiated adenocarcinoma (PD) and signet ring cell carcinoma (SRC). METHODS:From 2001 to 2011, 209 lesions in 209 patients with UD-EGC (82 PD; 127 SRC) were treated by ER. We retrospectively assessed the clinical outcomes of ER in 209 patients. The survival rate and disease-free survival rates after ER were evaluated as long-term outcomes. RESULTS:The en bloc resection and curative resection (CR) rates were 91.4 and 55.0 %, respectively. The en bloc and CR rates in PD were 90.2 and 45.1 %, whereas those in SRC were 92.1 and 61.4 %. For patients with PD who underwent non-curative resections, 51.1 % were vertical-cut end-positive and for those with SRC, 63.3 % were lateral-cut end-positive, a statistically significant difference. In those patients where CR was achieved, no case of local recurrence or distant metastasis was observed during the follow-up period (32.7 ± 22.2 months). The 3- and 5-year survival rates were 99.0 and 98.6 %, with no significant difference between CR patients with SRC and PD. CONCLUSIONS:ER may yield good long-term outcomes for UD-EGC if CR is achieved, with no difference between PD and SRC. However, to increase the current CR rate of ER, stricter criteria for performing ER in UD-EGC may be required.
Full Text
http://link.springer.com/article/10.1007%2Fs00464-014-3514-x
DOI
10.1007/s00464-014-3514-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Hoon(김용훈)
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Youn, Young Hoon(윤영훈) ORCID logo https://orcid.org/0000-0002-0071-229X
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Lee, Hyuk(이혁)
Jeon, Han Ho(전한호)
Jung, Da Hyun(정다현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99311
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