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Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury

Authors
 Kang Ju Lee  ;  Seung Hyun Park  ;  Ji Yong Lee  ;  Hyun Chel Joo  ;  Eui Hwa Jang  ;  Young-Nam Youn  ;  WonHyoung Ryu 
Citation
 JOURNAL OF CONTROLLED RELEASE, Vol.191C : 174-181, 2014 
Journal Title
JOURNAL OF CONTROLLED RELEASE
ISSN
 0168-3659 
Issue Date
2014
MeSH
Animals ; Aorta, Abdominal/drug effects ; Aorta, Abdominal/pathology* ; Disease Models, Animal ; Drug Delivery Systems/instrumentation* ; Equipment Design ; Hyperplasia/pathology ; Male ; Needles* ; Neointima/drug therapy* ; Neointima/pathology ; Rabbits ; Vascular System Injuries/complications*
Keywords
Drug delivery ; Grafting surgery ; Microneedles ; Neointimal hyperplasia ; Restenosis
Abstract
Restenosis often occurs at the site of vascular grafting and may become fatal for patients. Restenosis at anastomosis sites is due to neointimal hyperplasia (NH) and difficult to treat with conventional treatments. Such abnormal growth of smooth muscle cells in tunica media of vascular tissue can be reduced by delivering anti-proliferation drugs such as paclitaxel (PTX) to the inner vascular layer. Drug eluting stents (DES) or drug eluting balloon (DEB) have been developed to treat such vascular diseases. However, they are less efficient in drug delivery due to the drug loss to blood stream and inadequate to be applied to re-stenotic area in the presence of stent or anastomosis sites. Recently, we have introduced microneedle cuff (MNC) as perivascular delivery devices to achieve high delivery efficiency to tunica media. In this study, we investigated in vivo microneedle insertion and efficacy in treating NH using a rabbit balloon injury model. Microneedle shape was optimized for reliable insertion into tunica media layer. Uniform distribution of PTX in tunica media delivered by MNC devices was also confirmed. Animal study demonstrated significant NH reduction by MNC treatments and much higher delivery efficiency than flat type devices.
Full Text
http://www.sciencedirect.com/science/article/pii/S0168365914004763
DOI
10.1016/j.jconrel.2014.07.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Youn, Young Nam(윤영남)
Joo, Hyun Chel(주현철) ORCID logo https://orcid.org/0000-0002-6842-2942
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99247
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