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Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury

DC Field Value Language
dc.contributor.author주현철-
dc.contributor.author윤영남-
dc.date.accessioned2015-01-06T17:02:29Z-
dc.date.available2015-01-06T17:02:29Z-
dc.date.issued2014-
dc.identifier.issn0168-3659-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99247-
dc.description.abstractRestenosis often occurs at the site of vascular grafting and may become fatal for patients. Restenosis at anastomosis sites is due to neointimal hyperplasia (NH) and difficult to treat with conventional treatments. Such abnormal growth of smooth muscle cells in tunica media of vascular tissue can be reduced by delivering anti-proliferation drugs such as paclitaxel (PTX) to the inner vascular layer. Drug eluting stents (DES) or drug eluting balloon (DEB) have been developed to treat such vascular diseases. However, they are less efficient in drug delivery due to the drug loss to blood stream and inadequate to be applied to re-stenotic area in the presence of stent or anastomosis sites. Recently, we have introduced microneedle cuff (MNC) as perivascular delivery devices to achieve high delivery efficiency to tunica media. In this study, we investigated in vivo microneedle insertion and efficacy in treating NH using a rabbit balloon injury model. Microneedle shape was optimized for reliable insertion into tunica media layer. Uniform distribution of PTX in tunica media delivered by MNC devices was also confirmed. Animal study demonstrated significant NH reduction by MNC treatments and much higher delivery efficiency than flat type devices.-
dc.description.statementOfResponsibilityopen-
dc.format.extent174~181-
dc.relation.isPartOfJOURNAL OF CONTROLLED RELEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAorta, Abdominal/drug effects-
dc.subject.MESHAorta, Abdominal/pathology*-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHDrug Delivery Systems/instrumentation*-
dc.subject.MESHEquipment Design-
dc.subject.MESHHyperplasia/pathology-
dc.subject.MESHMale-
dc.subject.MESHNeedles*-
dc.subject.MESHNeointima/drug therapy*-
dc.subject.MESHNeointima/pathology-
dc.subject.MESHRabbits-
dc.subject.MESHVascular System Injuries/complications*-
dc.titlePerivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthorKang Ju Lee-
dc.contributor.googleauthorSeung Hyun Park-
dc.contributor.googleauthorJi Yong Lee-
dc.contributor.googleauthorHyun Chel Joo-
dc.contributor.googleauthorEui Hwa Jang-
dc.contributor.googleauthorYoung-Nam Youn-
dc.contributor.googleauthorWonHyoung Ryu-
dc.identifier.doi10.1016/j.jconrel.2014.07.007-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03960-
dc.contributor.localIdA02576-
dc.relation.journalcodeJ01352-
dc.identifier.eissn1873-4995-
dc.identifier.pmid25025286-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0168365914004763-
dc.subject.keywordDrug delivery-
dc.subject.keywordGrafting surgery-
dc.subject.keywordMicroneedles-
dc.subject.keywordNeointimal hyperplasia-
dc.subject.keywordRestenosis-
dc.contributor.alternativeNameJoo, Hyun Chel-
dc.contributor.alternativeNameYoun, Young Nam-
dc.contributor.affiliatedAuthorJoo, Hyun Chel-
dc.contributor.affiliatedAuthorYoun, Young Nam-
dc.rights.accessRightsfree-
dc.citation.volume191C-
dc.citation.startPage174-
dc.citation.endPage181-
dc.identifier.bibliographicCitationJOURNAL OF CONTROLLED RELEASE, Vol.191C : 174-181, 2014-
dc.identifier.rimsid55962-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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