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Association between Apolipoprotein B/Apolipoprotein A-1 and arterial stiffness in metabolic syndrome

Authors
 Min Kyung Kim  ;  Chul Woo Ahn  ;  Shinae Kang  ;  Ji Yoon Ha  ;  Haeri Baek  ;  Jong Suk Park  ;  Kyung Rae Kim 
Citation
 CLINICA CHIMICA ACTA, Vol.473C : 115-119, 2014 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2014
MeSH
Aged ; Apolipoprotein A-I/blood* ; Apolipoproteins B/blood* ; Biomarkers ; Cohort Studies ; Female ; Humans ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/diagnosis* ; Middle Aged ; Population Surveillance*/methods ; Vascular Stiffness/physiology*
Keywords
Apolipoprotein A-1 ; Apolipoprotein B ; Apolipoprotein B/Apolipoprotein A-1 ratio ; Arterial stiffness ; Metabolic syndrome
Abstract
BACKGROUND: Apolipoprotein B/Apolipoprotein A-1 ratio (Apo B/Apo A-1) is known to be associated with atherosclerotic vascular disease. However, few studies have investigated the relationship between Apo B/Apo A-1 ratio and arterial stiffness, thus we investigated the relationships between Apo B/Apo A-1 and arterial stiffness in patients with metabolic syndrome (MetS). METHODS:1252 subjects with MetS according to the Adult Treatment Panel III were enrolled in our study. Anthropometric profiles and serum concentrations of Apo B, Apo A-1, fasting plasma glucose (FPG), total cholesterol (TC), triglycerides (TG), and high density lipoprotein cholesterol (HDL-C) were measured. Pulse wave velocity (PWV) was evaluated to assess arterial stiffness. RESULTS:The subjects were stratified into four groups according to their Apo B/Apo A-1 ratios. PWV gradually increased according to Apo B/Apo A-1 quartiles. After adjusting for age, arterial stiffness was significantly correlated with systolic blood pressure, diastolic blood pressure, FPG, homeostasis model assessment (HOMA-IR), Apo B and Apo B/Apo A-1. In multiple logistic regression analysis after adjusting for risk factors, Apo B/Apo A-1 ratio was a significant contributor to increased PWV. CONCLUSION:These results suggest that Apo B/Apo A-1 is independently associated with increased arterial stiffness in patients with MetS.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898114002927
DOI
10.1016/j.cca.2014.07.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Ae(강신애) ORCID logo https://orcid.org/0000-0002-9719-4774
Kim, Kyung Rae(김경래)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Baek, Hae Ri(백혜리)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Ha, Ji Yoon(하지윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99246
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