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Relationship of Vitamin D Binding Protein Polymorphisms and Lung Function in Korean Chronic Obstructive Pulmonary Disease

 Ji Ye Jung  ;  Dong Pil Choi  ;  Sungho Won  ;  Young Lee  ;  Ju Hye Shin  ;  Young Sam Kim  ;  Se Kyu Kim  ;  Yeon Mok Oh  ;  Il Suh  ;  Sang-Do Lee 
 YONSEI MEDICAL JOURNAL, Vol.55(5) : 1318-1325, 2014 
Journal Title
Issue Date
Aged ; Female ; Forced Expiratory Volume ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic* ; Pulmonary Disease, Chronic Obstructive/genetics* ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiratory Function Tests ; Smoking ; Vitamin D-Binding Protein/chemistry ; Vitamin D-Binding Protein/genetics*
Vitamin D binding protein ; chronic obstructive pulmonary disease ; lung function ; polymorphism
PURPOSE: Multiple genetic factors are associated with chronic obstructive pulmonary disease (COPD). The association of gene encoding vitamin D binding protein (VDBP, GC) with COPD has been controversial. We sought to investigate the types of GC variants in the Korean population and determine the association of GC variants with COPD and lung function in the Korean population. MATERIALS AND METHODS:The study cohort consisted of 203 COPD patients and 157 control subjects. GC variants were genotyped by the restriction fragment-length polymorphism method. Repeated measures of lung function data were analyzed using a linear mixed model including sex, age, height, and pack-years of smoking to investigate the association of GC genetic factors and lung function. RESULTS:GC1F variant was most frequently observed in COPD (46.1%) and controls (42.0%). GC1S variant (29.0% vs. 21.4%; p=0.020) and genotype 1S-1S (8.3% vs. 3.4%; p=0.047) were more commonly detected in control than COPD. According to linear mixed model analysis including controls and COPD, subjects with genotype 1S-1S had 0.427 L higher forced expiratory volume in 1 second (FEV₁) than those with other genotypes (p=0.029). However, interaction between the genotype and smoking pack-year was found to be particularly significant among subjects with genotype 1S-1S; FEV₁ decreased by 0.014 L per smoking pack-year (p=0.001). CONCLUSION:This study suggested that GC polymorphism might be associated with lung function and risk of COPD in Korean population. GC1S variant and genotype 1S-1S were more frequently observed in control than in COPD. Moreover, GC1S variant was more common in non-decliners than in rapid decliners among COPD.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Kyu(김세규)
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Shin, Ju Hye(신주혜)
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
Choi, Dong Phil(최동필)
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