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Promotion of Full-ThicknessWound Healing Using Epigallocatechin-3-O-Gallate/Poly (Lactic-Co-Glycolic Acid) Membrane as Temporary Wound Dressing

Authors
 Hye-Lee Kim  ;  Jeong-Hyun Lee  ;  Byeong Ju Kwon  ;  Mi Hee Lee  ;  Dong-Wook Han  ;  Suong-Hyu Hyon  ;  Jong-Chul Park 
Citation
 Artificial Organs, Vol.38(5) : 411-417, 2014 
Journal Title
 Artificial Organs 
ISSN
 0160-564X 
Issue Date
2014
MeSH
Adult ; Animals ; Antioxidants/administration & dosage ; Antioxidants/therapeutic use* ; Bandages* ; Catechin/administration & dosage ; Catechin/analogs & derivatives* ; Catechin/therapeutic use ; Cell Line ; Humans ; Lactic Acid/chemistry* ; Male ; Membranes, Artificial ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Polyglycolic Acid/chemistry* ; Wound Healing/drug effects*
Keywords
Electrospinning ; Epigallocatechin-3-O-gallate ; Poly (lactic-co-glycolic acid) ; Temporary wound dressing ; Wound healing
Abstract
Epigallocatechin-3-O-gallate (EGCG) is a major polyphenolic compound in green tea. It has been known that EGCG regulates the secretion of cytokines and the activation of skin cells during wound healing. In this study, various concentrations of EGCG were added to the electrospun membranes composed of poly (lactic-co-glycolic acid) (PLGA), and its healing effects on full-thickness wounds created in nude mice were investigated. The electrospun membranes containing 5 wt% EGCG (5EGCG/PLGA membrane) exhibited cytotoxicity in human dermal fibroblasts (HDFs) as HDF morphologies were transformed on them. In the animal study, cell infiltration of mice treated with electrospun membranes containing 1 wt% EGCG (1EGCG/PLGA membrane) significantly increased after 2 weeks. The immunoreactivity of Ki-67 (re-epithelialization at the wound site) and CD 31 (formation of blood vessels) also increased in the mice treated with 1EGCG/PLGA membranes in comparison with the mice treated with PLGA membranes. These results suggest that 1EGCG/PLGA can enhance wound healing in full thickness by accelerating cell infiltration, re-epithelialization, and angiogenesis.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/aor.12190/abstract
DOI
10.1111/aor.12190
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Byeong-Ju(권병주) ORCID logo https://orcid.org/0000-0001-9916-0546
Kim, Hye Lee(김혜리)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
Lee, Jeong Hyun(이정현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99078
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