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The association between serum vitamin D level and immunoglobulin E in Korean adolescents

Authors
 Ju Wan Kang  ;  Jeong Hong Kim  ;  Joo-Heon Yoon  ;  Chang-Hoon Kim 
Citation
 INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, Vol.78(5) : 817-820, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 
ISSN
 0165-5876 
Issue Date
2014
MeSH
Asian Continental Ancestry Group/statistics & numerical data ; Biomarkers/blood ; Child ; Confidence Intervals ; Female ; Humans ; Hypersensitivity/ethnology ; Hypersensitivity/prevention & control* ; Immunoglobulin E/blood* ; Immunoglobulin E/immunology ; Korea ; Linear Models ; Male ; Multivariate Analysis ; Nutrition Surveys ; Sensitivity and Specificity ; Vitamin D/blood* ; Vitamin D/immunology
Keywords
Allergy ; Dermatophagoides farinae ; Immunoglobulin E ; Vitamin D
Abstract
OBJECTIVE: Vitamin D has immune modulatory functions, and thus its relationship with allergic disease has been evaluated in a number of studies. However, no concrete link between serum IgE level and vitamin D has been established. Thus, the purpose of study was to confirm the association of serum vitamin D level with the serum IgE (total and Dematophagoides farinae specific IgE) in Korean adolescents. METHODS: A total of 365 subjects between 10 and 18 years of age were enrolled through the Korea National Health and Nutrition Examination Survey (KNHANES). Serum levels of vitamin D, total IgE, and Dermatophagoides farinae (Df) specific IgE were measured, and data for potential confounding variables were collected. Multivariate regression analyses were used to determine the independent effects of these variables. RESULTS: Levels of both total and Df specific IgE were positively correlated with serum concentration of vitamin D (Spearman's rho (R)=0.126, p=0.016; R=0.152, p=0.004, respectively). These results were confirmed by multivariate linear regression analysis after adjusting for sex, age, and body mass index (coefficient (B): 10.45 95% confidence interval (CI): 0.59-20.31; B: 1.06, 95% CI: 0.31-1.80, respectively). And, the association between serum vitamin D and IgE showed the different results depending on the presence or absence of Df sensitization. CONCLUSIONS: Serum concentration of vitamin D was positively associated with levels of both total IgE and Df-specific IgE in Korean adolescents.
Full Text
http://www.sciencedirect.com/science/article/pii/S0165587614001104
DOI
10.1016/j.ijporl.2014.02.021
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ju Wan(강주완)
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Yoon, Joo Heon(윤주헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99010
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