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Treatment outcomes of sinonasal adenoid cystic carcinoma: 30 cases from a single institution

 Sang Yeob Seong  ;  Dong Woo Hyun  ;  Yoo Suk Kim  ;  Hyung-Ju Cho  ;  Jeung-Gweon Lee  ;  Joo-Heon Yoon  ;  Chang-Hoon Kim 
 Journal of Cranio-maxillo-facial Surgery, Vol.42(5) : 171-175, 2014 
Journal Title
 Journal of Cranio-maxillo-facial Surgery 
Issue Date
Adult ; Aged ; Carcinoma, Adenoid Cystic/secondary ; Carcinoma, Adenoid Cystic/surgery* ; Disease-Free Survival ; Early Detection of Cancer ; Female ; Follow-Up Studies ; Humans ; Male ; Maxillary Sinus Neoplasms/surgery ; Middle Aged ; Nasal Cavity/surgery ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Nose Neoplasms/surgery ; Paranasal Sinus Neoplasms/surgery* ; Prognosis ; Radiotherapy, Adjuvant ; Retrospective Studies ; Survival Rate ; Treatment Outcome
Adenoid cystic carcinoma ; Nasal cavity ; Paranasal sinus ; Prognostic factors ; Survival
OBJECTIVE: To establish the clinical features and prognostic factors of sinonasal adenoid cystic carcinoma (ACC). MATERIAL AND METHODS: Thirty patients with histopathological diagnosis of sinonasal ACC who were treated at Severance Hospital between 1990 and 2010 were included in this retrospective chart review study. RESULTS: The 5-year disease-specific survival and disease-free survival rates were 75.3% and 37.2%, respectively. The maxillary sinus (63.3%) and nasal cavity (23.3%) were the most common sites of primary tumour. Most patients were diagnosed with advanced-stage (III/IV) disease (80.0%) and had undergone surgery and postoperative radiotherapy (70.0%). The most common histopathological subtype was cribriform type (40.9%). Local recurrence rate and distant metastasis rates were 26.7% and 23.3%, respectively. The mean time from primary treatment to recurrence was 44.5 months. Sinonasal ACC patients with stage IV and T4 disease had significantly worse survival than those with low stage and T disease. Patients with local recurrence had worse disease-specific survival than those with distant recurrence. Distant metastasis was associated with disease-free survival but not disease-specific survival. CONCLUSION: Despite the frequent occurrence of distant metastasis, early diagnosis and effective local control seemed to be the most important factors influencing the survival of sinonasal ACC.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Seong, Sang Yeob(성상엽)
Yoon, Joo Heon(윤주헌)
Lee, Jeung Gweon(이정권)
Cho, Hyung Ju(조형주) ORCID logo https://orcid.org/0000-0002-2851-3225
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