Cited 9 times in
Synthesis and characterization of ethosomal contrast agents containing iodine for computed tomography (CT) imaging applications
DC Field | Value | Language |
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dc.contributor.author | 최병욱 | - |
dc.date.accessioned | 2015-01-06T16:53:54Z | - |
dc.date.available | 2015-01-06T16:53:54Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0898-2104 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98982 | - |
dc.description.abstract | As a first step in the development of novel liver-specific contrast agents using ethosomes for computed tomography (CT) imaging applications, we entrapped iodine within ethosomes, which are phospholipid vesicular carriers containing relatively high alcohol concentrations, synthesized using several types of alcohol, such as methanol, ethanol, and propanol. The iodine containing ethosomes that were prepared using methanol showed the smallest vesicle size (392 nm) and the highest CT density (1107 HU). The incorporation of cholesterol into the ethosomal contrast agents improved the stability of the ethosomes but made the vesicle size large. The ethosomal contrast agents were taken up well by macrophage cells and showed no cellular toxicity. The results demonstrated that ethosomes containing iodine, as prepared in this study, have potential as contrast agents for applications in CT imaging. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 124~129 | - |
dc.relation.isPartOf | JOURNAL OF LIPOSOME RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Contrast Media/chemical synthesis* | - |
dc.subject.MESH | Ethanol | - |
dc.subject.MESH | Liposomes/chemical synthesis* | - |
dc.subject.MESH | Liver/metabolism* | - |
dc.subject.MESH | Macrophages/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Microscopy, Electron, Transmission | - |
dc.subject.MESH | Phospholipids | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.subject.MESH | Triiodobenzoic Acids/administration & dosage* | - |
dc.title | Synthesis and characterization of ethosomal contrast agents containing iodine for computed tomography (CT) imaging applications | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Hanjin Shin | - |
dc.contributor.googleauthor | Young-Min Cho | - |
dc.contributor.googleauthor | Kangtaek Lee | - |
dc.contributor.googleauthor | Chang-Ha Lee | - |
dc.contributor.googleauthor | Byoung Wook Choi | - |
dc.contributor.googleauthor | Bumsang Kim | - |
dc.identifier.doi | 10.3109/08982104.2013.850592 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04059 | - |
dc.relation.journalcode | J01564 | - |
dc.identifier.eissn | 1532-2394 | - |
dc.identifier.pmid | 24188576 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/08982104.2013.850592 | - |
dc.subject.keyword | Computed tomography (CT) | - |
dc.subject.keyword | contrast agents | - |
dc.subject.keyword | ethosomes | - |
dc.subject.keyword | iodine | - |
dc.subject.keyword | liver | - |
dc.subject.keyword | macrophage | - |
dc.contributor.alternativeName | Choi, Byoung Wook | - |
dc.contributor.affiliatedAuthor | Choi, Byoung Wook | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 24 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 124 | - |
dc.citation.endPage | 129 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LIPOSOME RESEARCH, Vol.24(2) : 124-129, 2014 | - |
dc.identifier.rimsid | 54324 | - |
dc.type.rims | ART | - |
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