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A liquid crystal polymer-based neuromodulation system: an application on animal model of neuropathic pain

Authors
 Kyou Sik Min  ;  Choong Jae Lee  ;  Sang Beom Jun  ;  Jinhyung Kim  ;  Sung Eun Lee  ;  Jaewoo Shin  ;  Jin Woo Chang  ;  Sung June Kim 
Citation
 NEUROMODULATION, Vol.17(2) : 160-169, 2014 
Journal Title
NEUROMODULATION
ISSN
 1094-7159 
Issue Date
2014
MeSH
Animals ; Deep Brain Stimulation/methods* ; Disease Models, Animal* ; Electrodes, Implanted ; Male ; Neuralgia/physiopathology ; Neuralgia/psychology ; Neuralgia/therapy* ; Neurotransmitter Agents/administration & dosage* ; Polymers/administration & dosage* ; Rats ; Rats, Sprague-Dawley
Keywords
Electrodes ; implant ; motor cortex stimulation ; neuropathic pain ; neurostimulation
Abstract
OBJECTIVE:
We developed a custom-made miniaturized neural stimulation system with a liquid crystal polymer (LCP)-based electrode array for animal experiments. In order to verify the feasibility of the system, motor cortex stimulation (MCS) was applied on the rat pain model induced by sciatic nerve injury.
MATERIALS AND METHODS:
LCP is mechanically stable and chemically inert and has a much lower water absorption rate than other biocompatible polymers such as polyimide or parylene. In the present study, a film-type LCP substrate is used to microfabricate the cortical stimulation electrode array. A miniaturized electrical neuromodulation system is implemented using an application-specific integrated chip for generation of electrical stimulation current. In vivo experiment was performed using a rat neuropathic pain model induced by sciatic nerve injury. The electrodes were attached to the contralateral primary motor cortex, which processes the hind limb movement. Mechanical allodynia was measured before, during, and after electrical stimulation to determine the effects on pain threshold.
RESULTS:
Electrical stimulation into the brain structure processing pain perception was effective in alleviating neuropathic pain. The pain threshold of the rats increased more than fivefold during the electrical stimulation.
CONCLUSION:
We developed a miniaturized electrical stimulation system with a novel flexible LCP electrode array for MCS in rats. This system is expected to be used in studying various neurological diseases and examining in vivo brain function.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/ner.12093/abstract
DOI
10.1111/ner.12093
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Jin Hyung(김진형)
Shin, Jaewoo(신재우) ORCID logo https://orcid.org/0000-0002-6335-1292
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98958
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