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Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial

 Seok Kyo Seo  ;  Yeon Hong  ;  Bo Hyon Yun  ;  Seung Joo Chon  ;  Yeon Soo Jung  ;  Joo Hyun Park  ;  SiHyun Cho  ;  Young Sik Choi  ;  Byung Seok Lee 
 JOURNAL OF ETHNOPHARMACOLOGY, Vol.154(3) : 753-757, 2014 
Journal Title
Issue Date
Antioxidants/administration & dosage ; Antioxidants/metabolism* ; Antioxidants/pharmacology* ; Biomarkers/blood ; Double-Blind Method ; Female ; Humans ; Insulin Resistance ; Medicine, Korean Traditional ; Middle Aged ; Oxidative Stress/drug effects* ; Panax/chemistry* ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology* ; Postmenopause/blood ; Postmenopause/drug effects* ; Republic of Korea
Insulin resistance ; Oxidative stress ; Postmenopausal women ; Red ginseng
ETHNOPHARMACOLOGICAL RELEVANCE: Red ginseng (RG) has been widely used to treat various diseases in East Asian countries. Previous studies have shown the anti-oxidative and anti-diabetic effects of RG. This study aimed to investigate the effects of RG on oxidative stress and insulin resistance in postmenopausal women. MATERIALS AND METHODS: We performed a randomized, double-blind, placebo-controlled trial in 82 postmenopausal women aged 45-60 years. Participants were randomized to receive 3g red ginseng daily or placebo for 12 weeks. Antioxidant enzymes activity (superoxide dismutase, glutathione peroxidase) and oxidative stress markers (malondialdehyde, 8-hydroxydeoxyguanosine) were assessed, and the homeostatic model assessment of insulin resistance index was calculated at the baseline and at the end of the trial. RESULTS: A total of 71 postmenopausal women completed the study. Serum superoxide dismutase activity was significantly increased after the 12-week RG supplementation (P<0.001), and these changes were statistically significant compared with the placebo group (P=0.004). Serum malondialdehyde levels showed a tendency to decrease after the 12-week RG supplementation (P=0.001), but these changes were not statistically significant compared with the placebo group (P=0.064). No statistically significant changes in serum glutathione peroxidase and 8-hydroxydeoxyguanosine were noted. Further, RG supplementation showed no effects on fasting glucose, fasting insulin, and insulin resistance. CONCLUSIONS: The results suggest that RG may reduce oxidative stress by increasing antioxidant enzyme activity in postmenopausal women.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Park, Joo Hyun(박주현)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Chon, Seung Joo(전승주)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
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