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Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial

DC Field Value Language
dc.contributor.author전승주-
dc.contributor.author정연수-
dc.contributor.author조시현-
dc.contributor.author최영식-
dc.contributor.author박주현-
dc.contributor.author서석교-
dc.contributor.author윤보현-
dc.contributor.author이병석-
dc.date.accessioned2015-01-06T16:52:54Z-
dc.date.available2015-01-06T16:52:54Z-
dc.date.issued2014-
dc.identifier.issn0378-8741-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98949-
dc.description.abstractETHNOPHARMACOLOGICAL RELEVANCE: Red ginseng (RG) has been widely used to treat various diseases in East Asian countries. Previous studies have shown the anti-oxidative and anti-diabetic effects of RG. This study aimed to investigate the effects of RG on oxidative stress and insulin resistance in postmenopausal women. MATERIALS AND METHODS: We performed a randomized, double-blind, placebo-controlled trial in 82 postmenopausal women aged 45-60 years. Participants were randomized to receive 3g red ginseng daily or placebo for 12 weeks. Antioxidant enzymes activity (superoxide dismutase, glutathione peroxidase) and oxidative stress markers (malondialdehyde, 8-hydroxydeoxyguanosine) were assessed, and the homeostatic model assessment of insulin resistance index was calculated at the baseline and at the end of the trial. RESULTS: A total of 71 postmenopausal women completed the study. Serum superoxide dismutase activity was significantly increased after the 12-week RG supplementation (P<0.001), and these changes were statistically significant compared with the placebo group (P=0.004). Serum malondialdehyde levels showed a tendency to decrease after the 12-week RG supplementation (P=0.001), but these changes were not statistically significant compared with the placebo group (P=0.064). No statistically significant changes in serum glutathione peroxidase and 8-hydroxydeoxyguanosine were noted. Further, RG supplementation showed no effects on fasting glucose, fasting insulin, and insulin resistance. CONCLUSIONS: The results suggest that RG may reduce oxidative stress by increasing antioxidant enzyme activity in postmenopausal women.-
dc.description.statementOfResponsibilityopen-
dc.format.extent753~757-
dc.relation.isPartOfJOURNAL OF ETHNOPHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntioxidants/administration & dosage-
dc.subject.MESHAntioxidants/metabolism*-
dc.subject.MESHAntioxidants/pharmacology*-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance-
dc.subject.MESHMedicine, Korean Traditional-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOxidative Stress/drug effects*-
dc.subject.MESHPanax/chemistry*-
dc.subject.MESHPlant Extracts/administration & dosage-
dc.subject.MESHPlant Extracts/pharmacology*-
dc.subject.MESHPostmenopause/blood-
dc.subject.MESHPostmenopause/drug effects*-
dc.subject.MESHRepublic of Korea-
dc.titleAntioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorSeok Kyo Seo-
dc.contributor.googleauthorYeon Hong-
dc.contributor.googleauthorBo Hyon Yun-
dc.contributor.googleauthorSeung Joo Chon-
dc.contributor.googleauthorYeon Soo Jung-
dc.contributor.googleauthorJoo Hyun Park-
dc.contributor.googleauthorSiHyun Cho-
dc.contributor.googleauthorYoung Sik Choi-
dc.contributor.googleauthorByung Seok Lee-
dc.identifier.doi10.1016/j.jep.2014.04.051-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03527-
dc.contributor.localIdA03846-
dc.contributor.localIdA04114-
dc.contributor.localIdA01668-
dc.contributor.localIdA01888-
dc.contributor.localIdA02555-
dc.contributor.localIdA02795-
dc.relation.journalcodeJ01406-
dc.identifier.eissn1872-7573-
dc.identifier.pmid24814037-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S037887411400350X-
dc.subject.keywordInsulin resistance-
dc.subject.keywordOxidative stress-
dc.subject.keywordPostmenopausal women-
dc.subject.keywordRed ginseng-
dc.contributor.alternativeNameChon, Seung Joo-
dc.contributor.alternativeNameJeong, Yon Soo-
dc.contributor.alternativeNameCho, Si Hyun-
dc.contributor.alternativeNameChoi, Young Sik-
dc.contributor.alternativeNamePark, Joo Hyun-
dc.contributor.alternativeNameSeo, Seok Kyo-
dc.contributor.alternativeNameYun, Bo Hyon-
dc.contributor.alternativeNameLee, Byung Seok-
dc.contributor.affiliatedAuthorChon, Seung Joo-
dc.contributor.affiliatedAuthorCho, Si Hyun-
dc.contributor.affiliatedAuthorChoi, Young Sik-
dc.contributor.affiliatedAuthorPark, Joo Hyun-
dc.contributor.affiliatedAuthorSeo, Seok Kyo-
dc.contributor.affiliatedAuthorYun, Bo Hyon-
dc.contributor.affiliatedAuthorLee, Byung Seok-
dc.rights.accessRightsfree-
dc.citation.volume154-
dc.citation.number3-
dc.citation.startPage753-
dc.citation.endPage757-
dc.identifier.bibliographicCitationJOURNAL OF ETHNOPHARMACOLOGY, Vol.154(3) : 753-757, 2014-
dc.identifier.rimsid54302-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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