2 159

Cited 11 times in

Subjective cognitive decline predicts future deterioration in cognitively normal patients with Parkinson's disease.

Authors
 Jin Yong Hong  ;  Mun Kyung Sunwoo  ;  Seok Jong Chung  ;  Jee Hyun Ham  ;  Ji E. Lee  ;  Young H. Sohn  ;  Phil Hyu Lee 
Citation
 Neurobiology of Aging, Vol.35(7) : 1739-1743, 2014 
Journal Title
 Neurobiology of Aging 
ISSN
 0197-4580 
Issue Date
2014
Abstract
Increasing evidence suggests that subjective cognitive decline (SCD) is a potential predictor of future cognitive decline or dementia. We investigated whether SCD in patients with Parkinson's disease (PD) is a predictor of future cognitive decline. Forty-six cognitively normal patients with PD were selected using comprehensive neuropsychological tests, and classified depending on the presence (PD-SCD+, n = 25) or absence of SCD (PD-SCD−, n = 21). After a mean follow-up of 2.4 years, we repeated the cognitive assessments with the same subjects. The clinical characteristics and cognitive performance of the 2 groups did not differ at baseline. At the follow-up assessment, 11 patients in the PD-SCD+ group (44.0%) and 2 in the PD-SCD− group (9.5%) were diagnosed with mild cognitive impairment (MCI), and the PD-SCD+ patients showed more rapid decline in semantic fluency and visuospatial memory tasks than those in the PD-SCD− group. A multivariate logistic regression analysis showed that presence of SCD (odds ratio, 8.378; 95% confidential interval, 1.472–47.683, p = 0.017) and higher Unified PD Rating Scale motor score of 20 or more (odds ratio, 4.539; 95% confidential interval, 1.004–20.528; p = 0.049) were risk factors for incident MCI. Present results demonstrate that SCD in cognitively normal patients with PD is an independent risk factor for incident MCI and acts as a predictor for future cognitive decline.
Full Text
http://www.sciencedirect.com/science/article/pii/S019745801300585X
DOI
10.1016/j.neurobiolaging.2013.11.017
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
선우문경(Sunwoo, Mun Kyung)
손영호(Sohn, Young Ho)
이지은(Lee, Ji Eun)
이필휴(Lee, Phil Hyu)
정석종(Chung, Seok Jong) ORCID logo https://orcid.org/0000-0001-6086-3199
함지현(Ham, Jee Hyun)
홍진용(Hong, Jin Yong)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98944
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse