2 224

Cited 13 times in

Subjective cognitive decline predicts future deterioration in cognitively normal patients with Parkinson's disease.

Authors
 Jin Yong Hong  ;  Mun Kyung Sunwoo  ;  Seok Jong Chung  ;  Jee Hyun Ham  ;  Ji E. Lee  ;  Young H. Sohn  ;  Phil Hyu Lee 
Citation
 NEUROBIOLOGY OF AGING, Vol.35(7) : 1739-1743, 2014 
Journal Title
 NEUROBIOLOGY OF AGING 
ISSN
 0197-4580 
Issue Date
2014
MeSH
Aged ; Cognition* ; Cognitive Dysfunction/diagnosis* ; Female ; Follow-Up Studies ; Humans ; Logistic Models ; Male ; Middle Aged ; Neuropsychological Tests* ; Parkinson Disease/psychology* ; Predictive Value of Tests ; Risk Factors
Keywords
Mild cognitive impairment ; Parkinson's disease ; Semantic fluency ; Subjective cognitive decline ; Visuospatial memory
Abstract
Increasing evidence suggests that subjective cognitive decline (SCD) is a potential predictor of future cognitive decline or dementia. We investigated whether SCD in patients with Parkinson's disease (PD) is a predictor of future cognitive decline. Forty-six cognitively normal patients with PD were selected using comprehensive neuropsychological tests, and classified depending on the presence (PD-SCD+, n = 25) or absence of SCD (PD-SCD−, n = 21). After a mean follow-up of 2.4 years, we repeated the cognitive assessments with the same subjects. The clinical characteristics and cognitive performance of the 2 groups did not differ at baseline. At the follow-up assessment, 11 patients in the PD-SCD+ group (44.0%) and 2 in the PD-SCD− group (9.5%) were diagnosed with mild cognitive impairment (MCI), and the PD-SCD+ patients showed more rapid decline in semantic fluency and visuospatial memory tasks than those in the PD-SCD− group. A multivariate logistic regression analysis showed that presence of SCD (odds ratio, 8.378; 95% confidential interval, 1.472–47.683, p = 0.017) and higher Unified PD Rating Scale motor score of 20 or more (odds ratio, 4.539; 95% confidential interval, 1.004–20.528; p = 0.049) were risk factors for incident MCI. Present results demonstrate that SCD in cognitively normal patients with PD is an independent risk factor for incident MCI and acts as a predictor for future cognitive decline.
Full Text
http://www.sciencedirect.com/science/article/pii/S019745801300585X
DOI
10.1016/j.neurobiolaging.2013.11.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sunwoo, Mun Kyung(선우문경)
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
Ham, Jee Hyun(함지현)
Hong, Jin Yong(홍진용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98944
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse