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Subjective cognitive decline predicts future deterioration in cognitively normal patients with Parkinson's disease.

DC FieldValueLanguage
dc.contributor.author선우문경-
dc.contributor.author손영호-
dc.contributor.author이지은-
dc.contributor.author이필휴-
dc.contributor.author함지현-
dc.contributor.author홍진용-
dc.contributor.author정석종-
dc.date.accessioned2015-01-06T16:52:44Z-
dc.date.available2015-01-06T16:52:44Z-
dc.date.issued2014-
dc.identifier.issn0197-4580-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98944-
dc.description.abstractIncreasing evidence suggests that subjective cognitive decline (SCD) is a potential predictor of future cognitive decline or dementia. We investigated whether SCD in patients with Parkinson's disease (PD) is a predictor of future cognitive decline. Forty-six cognitively normal patients with PD were selected using comprehensive neuropsychological tests, and classified depending on the presence (PD-SCD+, n = 25) or absence of SCD (PD-SCD−, n = 21). After a mean follow-up of 2.4 years, we repeated the cognitive assessments with the same subjects. The clinical characteristics and cognitive performance of the 2 groups did not differ at baseline. At the follow-up assessment, 11 patients in the PD-SCD+ group (44.0%) and 2 in the PD-SCD− group (9.5%) were diagnosed with mild cognitive impairment (MCI), and the PD-SCD+ patients showed more rapid decline in semantic fluency and visuospatial memory tasks than those in the PD-SCD− group. A multivariate logistic regression analysis showed that presence of SCD (odds ratio, 8.378; 95% confidential interval, 1.472–47.683, p = 0.017) and higher Unified PD Rating Scale motor score of 20 or more (odds ratio, 4.539; 95% confidential interval, 1.004–20.528; p = 0.049) were risk factors for incident MCI. Present results demonstrate that SCD in cognitively normal patients with PD is an independent risk factor for incident MCI and acts as a predictor for future cognitive decline.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNEUROBIOLOGY OF AGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCognition*-
dc.subject.MESHCognitive Dysfunction/diagnosis*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests*-
dc.subject.MESHParkinson Disease/psychology*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRisk Factors-
dc.titleSubjective cognitive decline predicts future deterioration in cognitively normal patients with Parkinson's disease.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorJin Yong Hong-
dc.contributor.googleauthorMun Kyung Sunwoo-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorJee Hyun Ham-
dc.contributor.googleauthorJi E. Lee-
dc.contributor.googleauthorYoung H. Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1016/j.neurobiolaging.2013.11.017-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01935-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.contributor.localIdA04338-
dc.contributor.localIdA04442-
dc.contributor.localIdA03210-
dc.relation.journalcodeJ02322-
dc.identifier.eissn1558-1497-
dc.identifier.pmid24507441-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S019745801300585X-
dc.subject.keywordMild cognitive impairment-
dc.subject.keywordParkinson's disease-
dc.subject.keywordSemantic fluency-
dc.subject.keywordSubjective cognitive decline-
dc.subject.keywordVisuospatial memory-
dc.contributor.alternativeNameSunwoo, Mun Kyung-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Ji Eun-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.alternativeNameHong, Jin Yong-
dc.contributor.affiliatedAuthorSunwoo, Mun Kyung-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorHong, Jin Yong-
dc.contributor.affiliatedAuthorLee, Ji Eun-
dc.rights.accessRightsfree-
dc.citation.volume35-
dc.citation.number7-
dc.citation.startPage1739-
dc.citation.endPage1743-
dc.identifier.bibliographicCitationNEUROBIOLOGY OF AGING, Vol.35(7) : 1739-1743, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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