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Risk factors for the acquisition of carbapenem-resistant Escherichia coli at a tertiary care center in South Korea: A matched case-control study

 Jin Young Ahn  ;  Je Eun Song  ;  Min Hyung Kim  ;  Heun Choi  ;  Jae Kyung Kim  ;  Hea Won Ann  ;  Jung Ho Kim  ;  Yongduk Jeon  ;  Su Jin Jeong  ;  Sun Bean Kim  ;  Nam Su Ku  ;  Sang Hoon Han  ;  Young Goo Song  ;  Dongeun Yong  ;  Kyungwon Lee  ;  June Myung Kim  ;  Jun Yong Choi 
 American Journal of Infection Control, Vol.42(6) : 621-625, 2014 
Journal Title
 American Journal of Infection Control 
Issue Date
BACKGROUND: Carbapenem resistance among gram-negative bacilli is an emerging threat worldwide. The objective of this study was to identify risk factors for the acquisition of carbapenem-resistant Escherichia coli (CRE). METHODS: We conducted a matched case-control study comprising 57 cases of acquisition of CRE and 114 controls (1:2 matched) selected from patients with a culture of carbapenem-susceptible E coli between January 2006 and December 2010 at a 2000-bed tertiary care center in South Korea. RESULTS: On univariate analysis, previous use of carbapenem (P < .01), fluoroquinolone (P < .01), and glycopeptide (P < .01), as well as length of hospital stay (P < .05), were significantly associated with CRE acquisition. On multivariate analysis, previous use of carbapenem (odds ratio [OR], 4.56; 95% confidence interval [CI] 1.44-14.46; P = .01) and previous use of fluoroquinolone (OR, 2.81; 95% CI, 1.14-6.99; P = .03) were independent risk factors. CONCLUSIONS: At this institute, the antibiotic selective pressure of carbapenems and fluoroquinolones was shown to be an important risk factor for the acquisition of CRE.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
구남수(Ku, Nam Su) ORCID logo https://orcid.org/0000-0002-9717-4327
김민형(Kim, Min Hyung)
김선빈(Kim, Sun Bean)
김재경(Kim, Jae Kyoung)
김정호(Kim, Jung Ho)
김준명(Kim, June Myung)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
송제은(Song, Je Eun)
안진영(Ahn, Jin Young) ORCID logo https://orcid.org/0000-0002-3740-2826
안혜원(Ann, Hea Won)
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
전용덕(Jeon, Yong Duk)
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
최흔(Choi, Heun) ORCID logo https://orcid.org/0000-0002-9622-9381
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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