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Risk factors for the acquisition of carbapenem-resistant Escherichia coli at a tertiary care center in South Korea: A matched case-control study

Authors
 Jin Young Ahn  ;  Je Eun Song  ;  Min Hyung Kim  ;  Heun Choi  ;  Jae Kyung Kim  ;  Hea Won Ann  ;  Jung Ho Kim  ;  Yongduk Jeon  ;  Su Jin Jeong  ;  Sun Bean Kim  ;  Nam Su Ku  ;  Sang Hoon Han  ;  Young Goo Song  ;  Dongeun Yong  ;  Kyungwon Lee  ;  June Myung Kim  ;  Jun Yong Choi 
Citation
 AMERICAN JOURNAL OF INFECTION CONTROL, Vol.42(6) : 621-625, 2014 
Journal Title
AMERICAN JOURNAL OF INFECTION CONTROL
ISSN
 0196-6553 
Issue Date
2014
MeSH
Aged ; Anti-Bacterial Agents/pharmacology* ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/pharmacology* ; Carbapenems/therapeutic use ; Case-Control Studies ; Cross Infection/epidemiology* ; Cross Infection/microbiology ; Escherichia coli/drug effects* ; Escherichia coli Infections/epidemiology* ; Escherichia coli Infections/microbiology ; Female ; Fluoroquinolones/therapeutic use ; Humans ; Length of Stay ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; Tertiary Care Centers ; beta-Lactam Resistance*
Keywords
Antibiotic selective pressure ; Carbapenem resistance
Abstract
BACKGROUND:
Carbapenem resistance among gram-negative bacilli is an emerging threat worldwide. The objective of this study was to identify risk factors for the acquisition of carbapenem-resistant Escherichia coli (CRE).
METHODS:
We conducted a matched case-control study comprising 57 cases of acquisition of CRE and 114 controls (1:2 matched) selected from patients with a culture of carbapenem-susceptible E coli between January 2006 and December 2010 at a 2000-bed tertiary care center in South Korea.
RESULTS:
On univariate analysis, previous use of carbapenem (P < .01), fluoroquinolone (P < .01), and glycopeptide (P < .01), as well as length of hospital stay (P < .05), were significantly associated with CRE acquisition. On multivariate analysis, previous use of carbapenem (odds ratio [OR], 4.56; 95% confidence interval [CI] 1.44-14.46; P = .01) and previous use of fluoroquinolone (OR, 2.81; 95% CI, 1.14-6.99; P = .03) were independent risk factors.
CONCLUSIONS:
At this institute, the antibiotic selective pressure of carbapenems and fluoroquinolones was shown to be an important risk factor for the acquisition of CRE.
Full Text
http://www.sciencedirect.com/science/article/pii/S0196655314001692
DOI
10.1016/j.ajic.2014.02.024
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Min Hyung(김민형)
Kim, Sun Bean(김선빈)
Kim, Jae Kyoung(김재경)
Kim, Jung Ho(김정호) ORCID logo https://orcid.org/0000-0002-5033-3482
Kim, June Myung(김준명)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Song, Je Eun(송제은)
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Ann, Hea Won(안혜원)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeon, Yong Duk(전용덕)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Heun(최흔) ORCID logo https://orcid.org/0000-0002-9622-9381
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98872
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