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Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio: Novel Markers for Diagnosis and Prognosis in Patients with Idiopathic Sudden Sensorineural Hearing Loss

Authors
 Young Joon Seo  ;  Jun hui Jeong  ;  Jae Young Choi  ;  In Seok Moon 
Citation
 DISEASE MARKERS, Vol.2014 : 702807, 2014 
Journal Title
DISEASE MARKERS
ISSN
 0278-0240 
Issue Date
2014
MeSH
Adult ; Auditory Perception ; Biomarkers ; Blood Platelets/physiology* ; Case-Control Studies ; Female ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/immunology* ; Hearing Loss, Sensorineural/physiopathology ; Hearing Loss, Sudden/diagnosis ; Hearing Loss, Sudden/immunology* ; Hearing Loss, Sudden/physiopathology ; Humans ; Lymphocyte Count ; Lymphocytes/physiology* ; Male ; Middle Aged ; Neutrophils/physiology* ; Platelet Count ; Prognosis ; Retrospective Studies ; Risk Factors
Abstract
BACKGROUND:
We aim to provide useful evidence about the association of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with idiopathic sudden sensorineural hearing loss (ISSNHL) and its possibility of emerging as a cheap, reliable, and independent prognostic marker of ISSNHL.
METHODS:
348 patients diagnosed with ISSNHL were included in our retrospective data analysis. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as "recovered" and "unrecovered" according to their response to the treatment.
RESULTS:
Both mean NLR and PLR values of the ISSNHL patients were significantly higher than the control group (both P < 0.001). The NLR value was 5.98 ± 4.22 in the unrecovered group and 3.50 ± 3.38 in the recovered group (P < 0.001). After adjustment in a binary logistic regression model, only NLR value was associated with the recovery of ISSNHL (P = 0.001).
DISCUSSION:
We demonstrated for the first time that NLR and PLR values were significantly high in ISSNHL patients. Also the NLR level might be taken into account as a novel potential marker to predict the patients' prognosis in terms of recovery.
Files in This Item:
T201401188.pdf Download
DOI
10.1155/2014/702807
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Moon, In Seok(문인석) ORCID logo https://orcid.org/0000-0002-3951-5074
Seo, Young Joon(서영준)
Jeong, Jun Hui(정준희)
Choi, Jae Young(최재영) ORCID logo https://orcid.org/0000-0001-9493-3458
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98633
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