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Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio: Novel Markers for Diagnosis and Prognosis in Patients with Idiopathic Sudden Sensorineural Hearing Loss

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dc.contributor.author문인석-
dc.contributor.author서영준-
dc.contributor.author정준희-
dc.contributor.author최재영-
dc.date.accessioned2015-01-06T16:43:09Z-
dc.date.available2015-01-06T16:43:09Z-
dc.date.issued2014-
dc.identifier.issn0278-0240-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98633-
dc.description.abstractBACKGROUND: We aim to provide useful evidence about the association of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with idiopathic sudden sensorineural hearing loss (ISSNHL) and its possibility of emerging as a cheap, reliable, and independent prognostic marker of ISSNHL. METHODS: 348 patients diagnosed with ISSNHL were included in our retrospective data analysis. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as "recovered" and "unrecovered" according to their response to the treatment. RESULTS: Both mean NLR and PLR values of the ISSNHL patients were significantly higher than the control group (both P < 0.001). The NLR value was 5.98 ± 4.22 in the unrecovered group and 3.50 ± 3.38 in the recovered group (P < 0.001). After adjustment in a binary logistic regression model, only NLR value was associated with the recovery of ISSNHL (P = 0.001). DISCUSSION: We demonstrated for the first time that NLR and PLR values were significantly high in ISSNHL patients. Also the NLR level might be taken into account as a novel potential marker to predict the patients' prognosis in terms of recovery.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfDISEASE MARKERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAuditory Perception-
dc.subject.MESHBiomarkers-
dc.subject.MESHBlood Platelets/physiology*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHearing Loss, Sensorineural/diagnosis-
dc.subject.MESHHearing Loss, Sensorineural/immunology*-
dc.subject.MESHHearing Loss, Sensorineural/physiopathology-
dc.subject.MESHHearing Loss, Sudden/diagnosis-
dc.subject.MESHHearing Loss, Sudden/immunology*-
dc.subject.MESHHearing Loss, Sudden/physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHLymphocyte Count-
dc.subject.MESHLymphocytes/physiology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeutrophils/physiology*-
dc.subject.MESHPlatelet Count-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.titleNeutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio: Novel Markers for Diagnosis and Prognosis in Patients with Idiopathic Sudden Sensorineural Hearing Loss-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorYoung Joon Seo-
dc.contributor.googleauthorJun hui Jeong-
dc.contributor.googleauthorJae Young Choi-
dc.contributor.googleauthorIn Seok Moon-
dc.identifier.doi10.1155/2014/702807-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04173-
dc.contributor.localIdA01374-
dc.contributor.localIdA01894-
dc.contributor.localIdA03732-
dc.relation.journalcodeJ00743-
dc.identifier.eissn1875-8630-
dc.identifier.pmid24891755-
dc.contributor.alternativeNameMoon, In Seok-
dc.contributor.alternativeNameSeo, Young Joon-
dc.contributor.alternativeNameJeong, Jun Hui-
dc.contributor.alternativeNameChoi, Jae Young-
dc.contributor.affiliatedAuthorChoi, Jae Young-
dc.contributor.affiliatedAuthorMoon, In Seok-
dc.contributor.affiliatedAuthorSeo, Young Joon-
dc.contributor.affiliatedAuthorJeong, Jun Hui-
dc.citation.volume2014-
dc.citation.startPage702807-
dc.identifier.bibliographicCitationDISEASE MARKERS, Vol.2014 : 702807, 2014-
dc.identifier.rimsid38161-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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