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Assessment of Hepatic Fibrosis Regression by Transient Elastography in Patients with Chronic Hepatitis B Treated with Oral Antiviral Agents

 Ja Kyung Kim  ;  Dae Won Ma  ;  Kwan Sik Lee  ;  Yong-Han Paik 
 Journal of Korean Medical Science, Vol.29(4) : 570-575, 2014 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Administration, Oral ; Adult ; Aged ; Alanine Transaminase/blood ; Antiviral Agents/therapeutic use* ; Elasticity Imaging Techniques ; Female ; Hepatitis B, Chronic/drug therapy* ; Humans ; Liver/diagnostic imaging ; Liver Cirrhosis/diagnostic imaging* ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index
Elasticity Imaging Techniques ; Hepatitis B, Chronic ; Liver Cirrhosis ; Liver Stiffness ; Oral Antiviral Agents
Transient elastography (TE) has been used as a non-invasive method for liver stiffness measurement (LSM) in patients with chronic liver disease. This study was performed to assess the change of LSM by TE and to assess its clinical usefulness during long-term oral antiviral therapy in patients with chronic hepatitis B (CHB). We retrospectively reviewed 83 CHB patients. The mean interval between two LSM was 411.5 ± 149.5 days. Initial and follow-up LSM was 16.15 ± 12.41 kPa and 11.26 ± 7.36 kPa, respectively (P < 0.001). The degree of regression of liver stiffness was -2.03 ± 0.36% per month. The fibrosis stage classified by LSM value improved in 37 (44.6%) patients during oral antiviral therapy. Of the 30 (36.1%) patients with LSM ≥ 14.1 kPa (cirrhosis) at 1st LSM, 12 (40%) proved to no longer have cirrhosis (≥ 1 decrease in fibrosis stage) at 2nd LSM. LSM significantly decreased in both baseline high (> upper limit of normal [ULN] × 2) and low (≤ ULN × 2) alanine aminotransferase groups during antiviral therapy (P < 0.001; P = 0.001, respectively). Long-term oral antiviral therapy resulted in the improvement of liver stiffness in a substantial portion of patients with CHB. TE may be used a useful clinical tool to assess disease progression in CHB patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
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