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Adjusted color probability codes for peripapillary retinal nerve fiber layer thickness in healthy Koreans.

 Samin Hong  ;  Sang-Myung Kim  ;  Kyoungsoo Park  ;  Jun Mo Lee  ;  Chan Yun Kim  ;  Gong Je Seong 
 BMC OPHTHALMOLOGY, Vol.14(1) : 38-47, 2014 
Journal Title
Issue Date
Adult ; Aged ; Asian Continental Ancestry Group ; Color ; Female ; Humans ; Male ; Middle Aged ; Nerve Fibers* ; Optic Disk/anatomy & histology* ; Reference Values ; Reproducibility of Results ; Republic of Korea ; Retinal Ganglion Cells/cytology* ; Tomography, Optical Coherence/methods ; Tomography, Optical Coherence/standards* ; Young Adult
Glaucoma ; Optical coherence tomography ; Probability code ; Retinal nerve fiber layer
BACKGROUND: Though a newly developed spectral domain optical coherence tomography (OCT) is at the center of interests for many ophthalmologic researchers and clinicians, its own characteristics are not fully evaluated yet. The main purpose of this study was to establish the adjusted color probability codes for peripapillary retinal nerve fiber layer (RNFL) thickness in healthy Koreans and to compare them with original color codes provided by spectral domain OCT. METHODS: Two hundred ninety-five healthy Korean eyes were enrolled and their peripapillary RNFL thickness was measured by Cirrus OCT. For each decade of age, the normal thickness reference was determined on the basis of z-scores and the adjusted color probability codes were established. Then the agreements between adjusted and original color codes were calculated using weighted Kappa (Kw) coefficient. RESULTS: On the basis of Kw coefficient, the overall agreement between the adjusted and original probability color codes was not excellent (Kw range of 0.500 to 0.806). If the adjusted probability codes were assumed as a standard of comparison, the original color codes showed the false-negative in 11% of eyes and the false-positive in 0.3% of eyes for average RNFL thickness. CONCLUSIONS: Adjusted color probability codes judged by the Korean normative data showed a discrepancy with original codes. It implies that normal reference and adjusted probability codes for each ethnicity might be needed to determine whether a certain RNFL thickness is within normal range or not.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Hong, Sa Min(홍사민)
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