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Impact of Increased Orifice Size and Decreased Flow Velocity of Left Atrial Appendage on Stroke in Nonvalvular Atrial Fibrillation

DC FieldValueLanguage
dc.contributor.author이혜정-
dc.contributor.author정보영-
dc.contributor.author김영진-
dc.contributor.author이문형-
dc.contributor.author이정명-
dc.contributor.author박희남-
dc.contributor.author심재민-
dc.contributor.author엄재선-
dc.date.accessioned2015-01-06T16:38:21Z-
dc.date.available2015-01-06T16:38:21Z-
dc.date.issued2014-
dc.identifier.issn0002-9149-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98479-
dc.description.abstractThe structural and functional characteristics of left atrial appendage (LAA) in patients with atrial fibrillation (AF) with previous stroke remain incompletely elucidated. This study investigated whether a larger LAA orifice is related to decreased LAA flow velocity and stroke in nonvalvular AF. The dimension, morphology, and flow velocity of LAA were compared in patients with nonvalvular AF with (stroke group, n = 67, mean age 66 ± 9 years) and without ischemic stroke (no-stroke group, n = 151, mean age 56 ± 10 years). Compared with no-stroke group, the stroke group had larger LA dimension (4.7 ± 0.8 vs 4.2 ± 0.6 cm, p <0.001), larger LAA orifice area (4.5 ± 1.5 vs 3.0 ± 1.1 cm(2), p <0.001), and slower LAA flow velocity (36 ± 19 vs 55 ± 20 cm/s, p <0.001). LAA flow velocity was negatively correlated with LAA orifice size (R = -0.48, p <0.001). After adjustment for multiple potential confounding factors including CHA2DS2-VASc score, persistent AF, and LA dimension, large LAA orifice area (odds ratio 6.16, 95% confidence interval 2.67 to 14.18, p <0.001) and slow LAA velocity (odds ratio 3.59, 95% confidence interval 1.42 to 9.08, p = 0.007) were found to be significant risk factors of stroke. In patients with LAA flow velocity <37.0 cm/s, patients with large LAA orifice (>3.5 cm(2)) had greater incidence of stroke than those with LAA orifice of ≤3.5 cm(2) (75% vs 23%, p <0.001). In conclusion, LAA orifice enlargement was related to stroke risk in patients with nonvalvular AF even after adjustment for other risk factors, and it could be the cause of decreased flow velocity in LAA.-
dc.description.statementOfResponsibilityopen-
dc.format.extent963~969-
dc.relation.isPartOfAMERICAN JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAtrial Appendage/diagnostic imaging-
dc.subject.MESHAtrial Appendage/physiopathology*-
dc.subject.MESHAtrial Fibrillation/complications*-
dc.subject.MESHAtrial Fibrillation/diagnosis-
dc.subject.MESHAtrial Fibrillation/physiopathology-
dc.subject.MESHAtrial Function, Right/physiology*-
dc.subject.MESHBlood Flow Velocity/physiology*-
dc.subject.MESHBrain Ischemia/epidemiology-
dc.subject.MESHBrain Ischemia/etiology*-
dc.subject.MESHConfidence Intervals-
dc.subject.MESHEchocardiography, Transesophageal/methods*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultidetector Computed Tomography/methods*-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.titleImpact of Increased Orifice Size and Decreased Flow Velocity of Left Atrial Appendage on Stroke in Nonvalvular Atrial Fibrillation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorJung Myung Lee-
dc.contributor.googleauthorJaemin Shim-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorYoung Jin Kim-
dc.contributor.googleauthorHye-Jeong Lee-
dc.contributor.googleauthorHui-Nam Pak-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorBoyoung Joung-
dc.identifier.doi10.1016/j.amjcard.2013.11.058-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03609-
dc.contributor.localIdA02766-
dc.contributor.localIdA03099-
dc.contributor.localIdA01776-
dc.contributor.localIdA02206-
dc.contributor.localIdA02337-
dc.contributor.localIdA03320-
dc.contributor.localIdA00727-
dc.relation.journalcodeJ00071-
dc.identifier.eissn1879-1913 -
dc.identifier.pmid24462064-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0002914913024594-
dc.contributor.alternativeNameLee, Hye Jeong-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.alternativeNameKim, Young Jin-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.alternativeNameLee, Jung Myung-
dc.contributor.alternativeNamePak, Hui Nam-
dc.contributor.alternativeNameShim, Jae Min-
dc.contributor.alternativeNameUhm, Jae Sun-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.contributor.affiliatedAuthorLee, Jung Myung-
dc.contributor.affiliatedAuthorPak, Hui Nam-
dc.contributor.affiliatedAuthorShim, Jae Min-
dc.contributor.affiliatedAuthorUhm, Jae Sun-
dc.contributor.affiliatedAuthorLee, Hye Jeong-
dc.contributor.affiliatedAuthorKim, Young Jin-
dc.rights.accessRightsfree-
dc.citation.volume113-
dc.citation.number6-
dc.citation.startPage963-
dc.citation.endPage969-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF CARDIOLOGY, Vol.113(6) : 963-969, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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