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A feasibility study of a pH sensitive nanomedicine using doxorubicin loaded poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) micelles

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dc.contributor.author오영택-
dc.date.accessioned2015-01-06T16:37:57Z-
dc.date.available2015-01-06T16:37:57Z-
dc.date.issued2014-
dc.identifier.issn2050-750X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98467-
dc.description.abstractA polyelectrolyte block copolymer, poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) (P(Asp-g-Im)-PEG), with several advantages such as an easy synthesis, having a high molecular weight and the buffer capacity of a zwitterionic polymer backbone compared to poly(histidine) backbones, was presently investigated to evaluate its feasibility as a pH sensitive anticancer nanomedicine. Doxorubicin (DOX) loaded P(Asp-g-Im)-PEG micelles (DPHAIM) were prepared by the bottom flask and diafiltration methods, forming stable pH sensitive nano-systems. DPHAIM with a 28% loading capacity displayed a pH dependent behavior with respect to drug release and cytotoxicity. At pH values below 7.0, the cumulative DOX release and cell cytotoxicity were increased compared to those at physiological pH. Animal imaging after intravenous administration of the micelles revealed their accumulation by passive targeting to tumor tissue compared to other normal tissues. This pH sensitive nanovehicle based on P(Asp-g-Im)-PEG is implicated as a promising anticancer nanomedicine with less toxicity on normal tissues for effective tumor treatment.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1152~1159-
dc.relation.isPartOfJOURNAL OF MATERIALS CHEMISTRY B-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA feasibility study of a pH sensitive nanomedicine using doxorubicin loaded poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) micelles-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorEun Seong Lee-
dc.contributor.googleauthorJi Hoon Kim-
dc.contributor.googleauthorTaehoon Sim-
dc.contributor.googleauthorYu Seok Youn-
dc.contributor.googleauthorBeom-Jin Lee-
dc.contributor.googleauthorYoung Taik Oh-
dc.contributor.googleauthorKyung Taek Oh-
dc.identifier.doi10.1039/C3TB21379J-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02390-
dc.relation.journalcodeJ01573-
dc.identifier.eissn2050-7518-
dc.identifier.urlhttp://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/c3tb21379j#!divAbstract-
dc.contributor.alternativeNameOh, Young Taik-
dc.contributor.affiliatedAuthorOh, Young Taik-
dc.rights.accessRightsfree-
dc.citation.volume2-
dc.citation.number9-
dc.citation.startPage1152-
dc.citation.endPage1159-
dc.identifier.bibliographicCitationJOURNAL OF MATERIALS CHEMISTRY B, Vol.2(9) : 1152-1159, 2014-
dc.identifier.rimsid57609-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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