3 229

Cited 14 times in

Diffusion and Perfusion MRI Prediction of Progression-Free Survival in Patients With Hepatocellular Carcinoma Treated With Concurrent Chemoradiotherapy

DC FieldValueLanguage
dc.contributor.author김기황-
dc.contributor.author김명진-
dc.contributor.author박미숙-
dc.contributor.author박준용-
dc.contributor.author한광협-
dc.date.accessioned2015-01-06T16:37:14Z-
dc.date.available2015-01-06T16:37:14Z-
dc.date.issued2014-
dc.identifier.issn1053-1807-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98445-
dc.description.abstractPURPOSE: To assess whether MR perfusion and diffusion parameters taken before concurrent chemoradiotherapy (CCRT) are useful imaging biomarkers for predicting progression-free survival (PFS) in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Twenty patients with locally advanced HCC who had no treatment before CCRT underwent dynamic contrast-enhanced (DCE) and diffusion-weighted MRI. Mean values of the volume transfer constant (K(trans) ), reflex constant (Kep ), extravascular extracellular volume fraction (Ve ) and the apparent diffusion coefficient (ADC) were estimated on a region of interest. The best cutoff value for each factor was assessed to differentiate between patients who had PFS shorter or longer than the median PFS. Patients were dichotomized in terms of the cutoff value. The survival outcome of the two groups and the predictive ability of each factor on PFS were evaluated. RESULTS: Median time to PFS was 179 days. The best cutoff values for ADC, K(trans) , Kep , and Ve was 1.008 × 10(-3) mm(2) s(-1) , 0.108 min(-1) , 0.570 min(-1) , and 0.298%. Patients with higher ADC had significantly longer PFS than those with lower ADC(P < 0.0001). CONCLUSION: The ADC of HCC acquired before CCRT correlated with PFS and was valuable in the prediction of the clinical outcome of HCC treated with CCRT.-
dc.description.statementOfResponsibilityopen-
dc.format.extent286~292-
dc.relation.isPartOfJOURNAL OF MAGNETIC RESONANCE IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/pathology*-
dc.subject.MESHCarcinoma, Hepatocellular/therapy*-
dc.subject.MESHChemoradiotherapy*-
dc.subject.MESHDiffusion Magnetic Resonance Imaging/methods*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/pathology*-
dc.subject.MESHLiver Neoplasms/therapy*-
dc.subject.MESHMagnetic Resonance Angiography/methods*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTreatment Outcome-
dc.titleDiffusion and Perfusion MRI Prediction of Progression-Free Survival in Patients With Hepatocellular Carcinoma Treated With Concurrent Chemoradiotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKyung Ah Kim-
dc.contributor.googleauthorMi-Suk Park-
dc.contributor.googleauthorHyun-Jun Ji-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.contributor.googleauthorKi Whang Kim-
dc.identifier.doi10.1002/jmri.24161-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00345-
dc.contributor.localIdA00426-
dc.contributor.localIdA01463-
dc.contributor.localIdA01675-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ01567-
dc.identifier.eissn1522-2586-
dc.identifier.pmid24302545-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jmri.24161/abstract-
dc.subject.keywordDCE MRI-
dc.subject.keywordapparent diffusion coefficient-
dc.subject.keywordconcurrent chemoradiotherapy-
dc.subject.keyworddiffusion-weighted image-
dc.subject.keywordhepatocellular carcinoma-
dc.contributor.alternativeNameKim, Ki Whang-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.alternativeNamePark, Mi Sook-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Ki Whang-
dc.contributor.affiliatedAuthorKim, Myeong Jin-
dc.contributor.affiliatedAuthorPark, Mi-Suk-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.rights.accessRightsfree-
dc.citation.volume39-
dc.citation.number2-
dc.citation.startPage286-
dc.citation.endPage292-
dc.identifier.bibliographicCitationJOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.39(2) : 286-292, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.