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The effects of ErhBMP-2-/EGCG-coated BCP bone substitute on dehiscence around dental implants in dogs

 Y-S Shin  ;  J-Y Seo  ;  S-H Oh  ;  J-H Kim  ;  S-T Kim  ;  Y-B Park  ;  H-S Moon 
 ORAL DISEASES, Vol.20(3) : 281-287, 2014 
Journal Title
Issue Date
Animals ; Bone Morphogenetic Protein 2/pharmacology* ; Bone Substitutes* ; Catechin/analogs & derivatives* ; Catechin/pharmacology ; Dental Implants* ; Dental Prosthesis Design ; Dogs ; Guided Tissue Regeneration, Periodontal ; Hydroxyapatites* ; Osteogenesis/drug effects* ; Recombinant Proteins/pharmacology ; Titanium* ; Transforming Growth Factor beta/pharmacology*
ErhBMP-2 ; GBR ; biphasic calcium phosphate ; dehiscence defect ; epigallocatechin-3-gallate ; titanium barrier membrane
OBJECTIVES: The purpose was to evaluate the effect of Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2)-/epigallocatechin-3-gallate (EGCG)-coated biphasic calcium phosphate (BCP) and titanium barrier membrane on dehiscence defects in dogs. MATERIALS AND METHODS: In five mongrel dogs, the dehiscence bony defects around dental implants were surgically created and in total three implants were placed at edentulous ridge of which teeth had been extracted 12 weeks before. For the control group, BCP was applied to the dehiscence defect. For experimental groups, ErhBMP-2-coated BCP and ErhBMP-2-/EGCG-coated BCP were applied. The newly designed titanium barrier membrane was used to apply all the defects. The defects were evaluated histologically and histometrically after 12 weeks. The comparative statistics of the groups were obtained through Kruskal-Wallis test. RESULTS: In bone-to-implant contact (BIC), bone density (BD), bone regeneration height (BRH), and bone mineralization apposition rate (BMAR), differences among groups were not found. ErhBMP-2/EGCG group appeared to have higher value. In fluorescence analysis, bone remodeling around graft material was more active in the ErhBMP-2/EGCG group. CONCLUSION: Within the limit of this study, it is reasonable to assume that BMP-2-/EGCG-coated biphasic BCP and the newly designed titanium membrane were more beneficial in dehiscence defect healing with increased bone remodeling.
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2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jee Hwan(김지환) ORCID logo https://orcid.org/0000-0002-0872-4906
Moon, Hong Seok(문홍석) ORCID logo https://orcid.org/0000-0001-8118-8145
Park, Young Bum(박영범)
Shin, Yoo Seok(신유석) ORCID logo https://orcid.org/0000-0003-1121-2570
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