Cited 178 times in
Inflammation-associated lymphangiogenesis: A double-edged sword?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김한솔 | - |
dc.date.accessioned | 2015-01-06T16:35:02Z | - |
dc.date.available | 2015-01-06T16:35:02Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0021-9738 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98377 | - |
dc.description.abstract | Lymphangiogenesis and lymphatic vessel remodeling are complex biological processes frequently observed during inflammation. Accumulating evidence indicates that inflammation-associated lymphangiogenesis (IAL) is not merely an endpoint event, but actually a phenomenon actively involved in the pathophysiology of various inflammatory disorders. The VEGF-C/VEGFR-3 and VEGF-A/VEGF-R2 signaling pathways are two of the best-studied pathways in IAL. Methods targeting these molecules, such as prolymphangiogenic or antilymphatic treatments, were found to be beneficial in various preclinical and/or clinical studies. This Review focuses on the most recent achievements in the fields of lymphatic biology relevant to inflammatory conditions. Additionally, preclinical and clinical therapies that modulate IAL are summarized. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 936~942 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Angiogenic Proteins/physiology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Diabetes Mellitus/immunology | - |
dc.subject.MESH | Diabetes Mellitus/physiopathology | - |
dc.subject.MESH | Graft Rejection/immunology | - |
dc.subject.MESH | Graft Rejection/physiopathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation/physiopathology | - |
dc.subject.MESH | Inflammatory Bowel Diseases/immunology | - |
dc.subject.MESH | Inflammatory Bowel Diseases/physiopathology | - |
dc.subject.MESH | Lymphangiogenesis* | - |
dc.subject.MESH | Respiratory System/immunology | - |
dc.subject.MESH | Respiratory System/physiopathology | - |
dc.subject.MESH | Signal Transduction | - |
dc.title | Inflammation-associated lymphangiogenesis: A double-edged sword? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Honsoul Kim | - |
dc.contributor.googleauthor | Raghu P. Kataru | - |
dc.contributor.googleauthor | Gou Young Koh | - |
dc.identifier.doi | 10.1172/JCI71607 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01099 | - |
dc.relation.journalcode | J01322 | - |
dc.identifier.eissn | 1558-8238 | - |
dc.identifier.pmid | 24590279 | - |
dc.identifier.url | http://www.jci.org/articles/view/71607 | - |
dc.contributor.alternativeName | Kim, Hon Soul | - |
dc.contributor.affiliatedAuthor | Kim, Hon Soul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 124 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 936 | - |
dc.citation.endPage | 942 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL INVESTIGATION, Vol.124(3) : 936-942, 2014 | - |
dc.identifier.rimsid | 56562 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.