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A prospective phase II trial of s-1 and cisplatin-based chemoradiotherapy for locoregionally advanced esophageal cancer

DC FieldValueLanguage
dc.contributor.author이혁-
dc.contributor.author정현수-
dc.contributor.author조병철-
dc.contributor.author김대준-
dc.contributor.author차지혜-
dc.contributor.author김주항-
dc.contributor.author허진-
dc.contributor.author김충배-
dc.contributor.author김형일-
dc.contributor.author김혜련-
dc.contributor.author박준철-
dc.contributor.author배미경-
dc.contributor.author신성관-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.contributor.author이진구-
dc.contributor.author이창걸-
dc.contributor.author이창영-
dc.date.accessioned2015-01-06T16:34:30Z-
dc.date.available2015-01-06T16:34:30Z-
dc.date.issued2014-
dc.identifier.issn0344-5704-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98361-
dc.description.abstractPURPOSE: S-1 is a novel oral fluoropyrimidine anticancer agent designed to enhance clinical efficacy, reduce gastrointestinal toxicity, and enhance radiotherapy effectiveness. A phase II trial was conducted to evaluate the efficacy and safety of preoperative chemoradiation with S-1 and cisplatin in locoregionally advanced esophageal cancer. METHODS: Eligible patients had stage IIA-IVA esophageal cancer. Patients received two cycles of S-1 (days 1-14 and days 22-35) and cisplatin (days 1 and 22) with concurrent radiotherapy (50.4 Gy total; 1.8 Gy/fraction). Esophagectomy was performed between weeks 12 and 18 as determined by the specialist multidisciplinary team. RESULTS: Sixty patients were enrolled in this study between March 2008 and August 2011, and 59 were eligible. The clinical stage was ≥T3 in 28 patients (47 %) and N1 in 43 patients (72 %), with squamous cell carcinoma histology in 58 patients (97 %). Fifty-four patients (90 %) completed the planned chemoradiation. After chemoradiation, the clinical tumor response rate was 64.4 %. The primary toxicities included neutropenia (24 %) and esophagitis (8.5 %). Three treatment-related deaths were noted. Twenty-five patients (42 %) underwent esophagectomy following chemoradiation, and 15 achieved complete pathologic regression. The estimated overall survival and progression-free survival rates after 2 years were 65 and 48 %, respectively. CONCLUSIONS: Concurrent chemoradiation with S-1 and cisplatin exhibited encouraging results with complete pathologic regression. The survival data were promising compared with the historical data of 5FU/cisplatin and should be confirmed in a randomized phase III trial. Toxicities were significant but clinically manageable.-
dc.description.statementOfResponsibilityopen-
dc.format.extent665~671-
dc.relation.isPartOfCancer Chemotherapy and Pharmacology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA prospective phase II trial of s-1 and cisplatin-based chemoradiotherapy for locoregionally advanced esophageal cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorHyun Chang-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorByoung Chul Cho-
dc.contributor.googleauthorChang-Geol Lee-
dc.contributor.googleauthorChoong Bai Kim-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorJin Gu Lee-
dc.contributor.googleauthorJin Hur-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorMi Kyung Bae-
dc.contributor.googleauthorHye Ryun Kim-
dc.contributor.googleauthorSang Kil Lee-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorHyuk Lee-
dc.contributor.googleauthorHyoung-Il Kim-
dc.contributor.googleauthorHyunsoo Chung-
dc.contributor.googleauthorJihye Cha-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorJoo-Hang Kim-
dc.identifier.doi10.1007/s00280-013-2371-y-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03285-
dc.contributor.localIdA03822-
dc.contributor.localIdA00368-
dc.contributor.localIdA04009-
dc.contributor.localIdA00945-
dc.contributor.localIdA04370-
dc.contributor.localIdA01063-
dc.contributor.localIdA01154-
dc.contributor.localIdA01166-
dc.contributor.localIdA01676-
dc.contributor.localIdA01792-
dc.contributor.localIdA02112-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.contributor.localIdA03225-
dc.contributor.localIdA03240-
dc.contributor.localIdA03245-
dc.relation.journalcodeJ00437-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00280-013-2371-y-
dc.contributor.alternativeNameLee, Hyuk-
dc.contributor.alternativeNameChung, Hyun Soo-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.alternativeNameCha, Ji Hye-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameHur, Jin-
dc.contributor.alternativeNameKim, Choong Bai-
dc.contributor.alternativeNameKim, Hyoung Il-
dc.contributor.alternativeNameKim, Hye Ryun-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNameBae, Mi Kyung-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLee, Jin Gu-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.alternativeNameLee, Chang Young-
dc.contributor.affiliatedAuthorLee, Hyuk-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorCha, Ji Hye-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorHur, Jin-
dc.contributor.affiliatedAuthorKim, Choong Bai-
dc.contributor.affiliatedAuthorKim, Hyoung Il-
dc.contributor.affiliatedAuthorKim, Hye Ryun-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorBae, Mi Kyung-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Jin Gu-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.contributor.affiliatedAuthorLee, Chang Young-
dc.rights.accessRightsfree-
dc.citation.volume73-
dc.citation.number4-
dc.citation.startPage665-
dc.citation.endPage671-
dc.identifier.bibliographicCitationCancer Chemotherapy and Pharmacology, Vol.73(4) : 665-671, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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