Cited 23 times in
A prospective phase II trial of s-1 and cisplatin-based chemoradiotherapy for locoregionally advanced esophageal cancer
DC Field | Value | Language |
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dc.contributor.author | 이혁 | - |
dc.contributor.author | 정현수 | - |
dc.contributor.author | 조병철 | - |
dc.contributor.author | 김대준 | - |
dc.contributor.author | 차지혜 | - |
dc.contributor.author | 김주항 | - |
dc.contributor.author | 허진 | - |
dc.contributor.author | 김충배 | - |
dc.contributor.author | 김형일 | - |
dc.contributor.author | 김혜련 | - |
dc.contributor.author | 박준철 | - |
dc.contributor.author | 배미경 | - |
dc.contributor.author | 신성관 | - |
dc.contributor.author | 이상길 | - |
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | 이창영 | - |
dc.date.accessioned | 2015-01-06T16:34:30Z | - |
dc.date.available | 2015-01-06T16:34:30Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0344-5704 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98361 | - |
dc.description.abstract | PURPOSE: S-1 is a novel oral fluoropyrimidine anticancer agent designed to enhance clinical efficacy, reduce gastrointestinal toxicity, and enhance radiotherapy effectiveness. A phase II trial was conducted to evaluate the efficacy and safety of preoperative chemoradiation with S-1 and cisplatin in locoregionally advanced esophageal cancer. METHODS: Eligible patients had stage IIA-IVA esophageal cancer. Patients received two cycles of S-1 (days 1-14 and days 22-35) and cisplatin (days 1 and 22) with concurrent radiotherapy (50.4 Gy total; 1.8 Gy/fraction). Esophagectomy was performed between weeks 12 and 18 as determined by the specialist multidisciplinary team. RESULTS: Sixty patients were enrolled in this study between March 2008 and August 2011, and 59 were eligible. The clinical stage was ≥T3 in 28 patients (47 %) and N1 in 43 patients (72 %), with squamous cell carcinoma histology in 58 patients (97 %). Fifty-four patients (90 %) completed the planned chemoradiation. After chemoradiation, the clinical tumor response rate was 64.4 %. The primary toxicities included neutropenia (24 %) and esophagitis (8.5 %). Three treatment-related deaths were noted. Twenty-five patients (42 %) underwent esophagectomy following chemoradiation, and 15 achieved complete pathologic regression. The estimated overall survival and progression-free survival rates after 2 years were 65 and 48 %, respectively. CONCLUSIONS: Concurrent chemoradiation with S-1 and cisplatin exhibited encouraging results with complete pathologic regression. The survival data were promising compared with the historical data of 5FU/cisplatin and should be confirmed in a randomized phase III trial. Toxicities were significant but clinically manageable. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 665~671 | - |
dc.relation.isPartOf | CANCER CHEMOTHERAPY AND PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | Chemoradiotherapy | - |
dc.subject.MESH | Cisplatin/administration & dosage | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Esophageal Neoplasms/drug therapy* | - |
dc.subject.MESH | Esophageal Neoplasms/pathology | - |
dc.subject.MESH | Esophageal Neoplasms/radiotherapy* | - |
dc.subject.MESH | Esophageal Neoplasms/surgery | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Oxonic Acid/administration & dosage | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Tegafur/administration & dosage | - |
dc.title | A prospective phase II trial of s-1 and cisplatin-based chemoradiotherapy for locoregionally advanced esophageal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Hyun Chang | - |
dc.contributor.googleauthor | Sung Kwan Shin | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.contributor.googleauthor | Chang-Geol Lee | - |
dc.contributor.googleauthor | Choong Bai Kim | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.contributor.googleauthor | Jin Hur | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | Mi Kyung Bae | - |
dc.contributor.googleauthor | Hye Ryun Kim | - |
dc.contributor.googleauthor | Sang Kil Lee | - |
dc.contributor.googleauthor | Jun Chul Park | - |
dc.contributor.googleauthor | Hyuk Lee | - |
dc.contributor.googleauthor | Hyoung-Il Kim | - |
dc.contributor.googleauthor | Hyunsoo Chung | - |
dc.contributor.googleauthor | Jihye Cha | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.contributor.googleauthor | Joo-Hang Kim | - |
dc.identifier.doi | 10.1007/s00280-013-2371-y | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03285 | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A00368 | - |
dc.contributor.localId | A04009 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A04370 | - |
dc.contributor.localId | A01063 | - |
dc.contributor.localId | A01154 | - |
dc.contributor.localId | A01166 | - |
dc.contributor.localId | A01676 | - |
dc.contributor.localId | A01792 | - |
dc.contributor.localId | A02112 | - |
dc.contributor.localId | A02812 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03240 | - |
dc.contributor.localId | A03245 | - |
dc.relation.journalcode | J00437 | - |
dc.identifier.eissn | 1432-0843 | - |
dc.identifier.pmid | 24562525 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00280-013-2371-y | - |
dc.subject.keyword | S-1 | - |
dc.subject.keyword | Cisplatin | - |
dc.subject.keyword | Esophageal cancer | - |
dc.subject.keyword | Chemoradiotherapy | - |
dc.subject.keyword | Preoperative | - |
dc.contributor.alternativeName | Lee, Hyuk | - |
dc.contributor.alternativeName | Chung, Hyun Soo | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.alternativeName | Cha, Ji Hye | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.alternativeName | Hur, Jin | - |
dc.contributor.alternativeName | Kim, Choong Bai | - |
dc.contributor.alternativeName | Kim, Hyoung Il | - |
dc.contributor.alternativeName | Kim, Hye Ryun | - |
dc.contributor.alternativeName | Park, Jun Chul | - |
dc.contributor.alternativeName | Bae, Mi Kyung | - |
dc.contributor.alternativeName | Shin, Sung Kwan | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.alternativeName | Lee, Chang Young | - |
dc.contributor.affiliatedAuthor | Lee, Hyuk | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Kim, Dae Joon | - |
dc.contributor.affiliatedAuthor | Cha, Ji Hye | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Hur, Jin | - |
dc.contributor.affiliatedAuthor | Kim, Choong Bai | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Il | - |
dc.contributor.affiliatedAuthor | Kim, Hye Ryun | - |
dc.contributor.affiliatedAuthor | Park, Jun Chul | - |
dc.contributor.affiliatedAuthor | Bae, Mi Kyung | - |
dc.contributor.affiliatedAuthor | Shin, Sung Kwan | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Lee, Chang Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 73 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 665 | - |
dc.citation.endPage | 671 | - |
dc.identifier.bibliographicCitation | CANCER CHEMOTHERAPY AND PHARMACOLOGY, Vol.73(4) : 665-671, 2014 | - |
dc.identifier.rimsid | 56552 | - |
dc.type.rims | ART | - |
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