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Cited 3 times in

IgE reactivity to Acarus siro extract in Korean dust mite allergic patients

DC FieldValueLanguage
dc.contributor.author손민아-
dc.contributor.author이재현-
dc.contributor.author정경용-
dc.contributor.author박중원-
dc.date.accessioned2015-01-06T16:33:50Z-
dc.date.available2015-01-06T16:33:50Z-
dc.date.issued2014-
dc.identifier.issn0168-8162-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98341-
dc.description.abstractAlthough specific IgE to the storage mite Acarus siro is often detected, there are no detailed studies on IgE reactivity to A. siro in Korea. This study was undertaken to investigate the cross-reactivity to the mite species Dermatophagoides pteronyssinus, Dermatophagoides farinae, Tyrophagus putrescentiae, and A. siro in Korean mite allergic patients. Specific IgE values were determined for the four mite species and a competitive inhibition test was performed for mite extracts using the ImmunoCAP system. The IgE value to D. farinae was the highest among the four mite species tested. There was a strong correlation in the IgE value between house dust mites (D. pteronyssinus and D. farinae) and between storage mites (A. siro and T. putrescentiae). IgE reactivity to A. siro was inhibited by D. farinae and T. putrescentiae extract. Dermatophagoides farinae extract was the strongest inhibitor of IgE binding to A. siro extract, indicating that IgE reactivity to A. siro extract is a cross-reaction caused by sensitization to D. farinae. Strong IgE reactive components were observed in D. farinae and T. putrescentiae extract by SDS-PAGE and IgE immunoblotting. However, no strong IgE-binding component was observed for A. siro. Dermatophagoides farinae is the main source of mite allergens that cause sensitization in Korea. Serum IgE from some of the house dust mite-sensitized patients showed positive responses to storage mite allergens by cross-reaction. Therefore, it is necessary to pay special attention to the diagnosis of mite allergies.-
dc.description.statementOfResponsibilityopen-
dc.format.extent57~64-
dc.relation.isPartOfExperimental and Applied Acarology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, Dermatophagoides/immunology*-
dc.subject.MESHCross Reactions-
dc.subject.MESHHypersensitivity/diagnosis*-
dc.subject.MESHImmunoglobulin E/immunology*-
dc.subject.MESHPyroglyphidae/immunology*-
dc.subject.MESHRepublic of Korea-
dc.titleIgE reactivity to Acarus siro extract in Korean dust mite allergic patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorMina Son-
dc.contributor.googleauthorKyoung Yong Jeong-
dc.contributor.googleauthorBum Joon Kim-
dc.contributor.googleauthorKook-Jin Lim-
dc.contributor.googleauthorJae-Hyun Lee-
dc.contributor.googleauthorJung-Won Park-
dc.identifier.doi10.1007/s10493-013-9759-6-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01969-
dc.contributor.localIdA03086-
dc.contributor.localIdA03572-
dc.contributor.localIdA01681-
dc.relation.journalcodeJ00858-
dc.identifier.pmid24287899-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10493-013-9759-6-
dc.subject.keywordAllergen-
dc.subject.keywordCross-reactivity-
dc.subject.keywordDust mites-
dc.contributor.alternativeNameSon, Min A-
dc.contributor.alternativeNameLee, Jae Hyun-
dc.contributor.alternativeNameJeong, Kyoung Yong-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.affiliatedAuthorSon, Min A-
dc.contributor.affiliatedAuthorLee, Jae Hyun-
dc.contributor.affiliatedAuthorJeong, Kyoung Yong-
dc.contributor.affiliatedAuthorPark, Jung Won-
dc.rights.accessRightsfree-
dc.citation.volume63-
dc.citation.number1-
dc.citation.startPage57-
dc.citation.endPage64-
dc.identifier.bibliographicCitationExperimental and Applied Acarology, Vol.63(1) : 57-64, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Allergy (알레르기연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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