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Do the abnormal results of an implantation renal biopsy affect the donor renal function?

 K.H. Choi  ;  S.C. Yang  ;  D.J. Joo  ;  Y.E. Yoon  ;  K.H. Kim  ;  K. Lee  ;  M.S. Kim  ;  Y.S. Kim  ;  S.I. Kim  ;  W.K. Han 
 Transplantation Proceedings, Vol.46(2) : 359-362, 2014 
Journal Title
 Transplantation Proceedings 
Issue Date
BACKGROUND: Living kidney donation has become an important source for renal transplantation. Thus, renal function after donation is an important issue. In this study, we examined histological abnormalities in implantation biopsy specimens from living kidney donors and analyzed the renal function of the remaining kidney. METHODS: Using the 2007 Banff classification system, we analyzed 121 kidneys from living donors who underwent implantation biopsies (IBs) between 2010 and 2011. Donor characteristics, intraoperative factors, and perioperative renal functions, such as serum creatinine and glomerular filtration rate (GFR), were evaluated. Univariate and multivariate regression analyses were performed to identify the factors related to each histological abnormality and postoperative 1-year donor renal function. RESULTS: Most histological abnormalities in healthy living donors were scored as 1 on the Banff scale. Univariate and multivariate analyses revealed that donor age was the only preoperative factor related to tubular atrophy (odds ratio [OR] = 1.104; P = .012) and glomerular sclerosis (OR = 1.050; P = .019). Intraoperative factors were not related to histological parameters. And histological abnormalities did not affect postoperative 1-year renal function. In contrast, donor age, preoperative GFR, and estimated blood loss were significantly related to 1-year postoperative GFR. CONCLUSION: Most histological abnormalities in healthy living donors were minor. The incidence of abnormalities correlated with donor age. However, postoperative renal functions in living donors were not affected by histological abnormalities. Larger-scale investigations with long-term follow-up analysis will be needed.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
김광현(Kim, Kwang Hyun)
김명수(Kim, Myoung Soo) ORCID logo https://orcid.org/0000-0002-8975-8381
김순일(Kim, Soon Il) ORCID logo https://orcid.org/0000-0002-0783-7538
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
양승철(Yang, Seung Choul)
윤영은(Yoon, Young Eun)
주동진(Joo, Dong Jin) ORCID logo https://orcid.org/0000-0001-8405-1531
최경화(Choi, Kyung Hwa)
한웅규(Han, Woong Kyu) ORCID logo https://orcid.org/0000-0002-2527-4046
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