Cited 41 times in
Thyroid Nodules with Benign Findings at Cytologic Examination: Results of Long-term Follow-up with US
DC Field | Value | Language |
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dc.contributor.author | 곽진영 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 문희정 | - |
dc.contributor.author | 정웅윤 | - |
dc.contributor.author | 한경화 | - |
dc.date.accessioned | 2015-01-06T16:33:18Z | - |
dc.date.available | 2015-01-06T16:33:18Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0033-8419 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98324 | - |
dc.description.abstract | PURPOSE: To investigate the natural history of thyroid nodules found to be benign at initial fine-needle aspiration biopsy (FNAB) to determine the percentage of nodules that increased in volume by more than 50% as being an indicator of malignancy. MATERIALS AND METHODS: This retrospective observational cohort study was approved by the institutional review board, and the need to obtain informed consent was waived. The study included 854 FNAB-confirmed benign thyroid nodules. Suspicious ultrasonographic (US) features included marked hypoechogenicity, irregular or microlobulated margin, microcalcification, and taller-than-wide shape. Univariate and multivariate generalized linear mixed models were used to assess the association with nodule growth greater than 50% in volume. RESULTS: For the 854 nodules, the initial mean diameter was 19.92 mm (range, 3.10-60.00 mm), and the initial mean volume was 3.19 cm(3) (range, 0.01-4.64 cm(3)). The majority (682 [79.9%] of 854) of thyroid nodules with benign cytologic results at initial FNAB did not grow more than 50% in volume during 4 years of mean follow-up (range, 7-101 months). More than 4 years of follow-up time versus less than 2 years, younger age, a cystic component of less than 25%, and nodule size 1 cm or larger versus less than 1 cm were independently associated with growth. There was only one malignant nodule (0.6%) among 172 thyroid nodules with a volume increase of 50% or greater during the entire follow-up time. Ten malignant nodules (overall malignancy rate: 1.2%) were detected among the 854 total nodules, and eight of these 10 nodules showed suspicious features at US. CONCLUSION: Repeat FNAB for nodules showing more than 50% growth in volume is unlikely to result in a diagnosis of malignancy. A positive FNAB result for malignancy is significantly more likely in the presence of suspicious US features. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 272~281 | - |
dc.relation.isPartOf | RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biopsy, Fine-Needle* | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Thyroid Neoplasms/diagnostic imaging | - |
dc.subject.MESH | Thyroid Neoplasms/pathology* | - |
dc.subject.MESH | Thyroid Nodule/diagnostic imaging | - |
dc.subject.MESH | Thyroid Nodule/pathology* | - |
dc.subject.MESH | Ultrasonography, Interventional | - |
dc.title | Thyroid Nodules with Benign Findings at Cytologic Examination: Results of Long-term Follow-up with US | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Soo-Yeon Kim | - |
dc.contributor.googleauthor | Kyung Hwa Han | - |
dc.contributor.googleauthor | Hee Jung Moon | - |
dc.contributor.googleauthor | Jin Young Kwak | - |
dc.contributor.googleauthor | Woong Youn Chung | - |
dc.contributor.googleauthor | Eun-Kyung Kim | - |
dc.identifier.doi | 10.1148/radiol.13131334 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00182 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01397 | - |
dc.contributor.localId | A03674 | - |
dc.contributor.localId | A04267 | - |
dc.relation.journalcode | J02596 | - |
dc.identifier.eissn | 1527-1315 | - |
dc.identifier.pmid | 24475857 | - |
dc.identifier.url | http://pubs.rsna.org/doi/abs/10.1148/radiol.13131334 | - |
dc.contributor.alternativeName | Kwak, Jin Young | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.alternativeName | Moon, Heui Jeong | - |
dc.contributor.alternativeName | Chung, Woung Youn | - |
dc.contributor.alternativeName | Han, Kyung Hwa | - |
dc.contributor.affiliatedAuthor | Kwak, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Moon, Heui Jeong | - |
dc.contributor.affiliatedAuthor | Chung, Woung Youn | - |
dc.contributor.affiliatedAuthor | Han, Kyung Hwa | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 271 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 272 | - |
dc.citation.endPage | 281 | - |
dc.identifier.bibliographicCitation | RADIOLOGY, Vol.271(1) : 272-281, 2014 | - |
dc.identifier.rimsid | 51839 | - |
dc.type.rims | ART | - |
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