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Indenter study: Associations between prostate elasticity and lower urinary tract symptoms

 Kwang Hyun Kim  ;  Bummo Ahn  ;  Sey Kiat Lim  ;  Woong Kyu Han  ;  Jang Hwan Kim  ;  Koon Ho Rha  ;  Jung Kim 
 UROLOGY, Vol.83(3) : 544-548, 2014 
Journal Title
Issue Date
Aged ; Elastic Modulus/physiology* ; Humans ; Lower Urinary Tract Symptoms/etiology ; Lower Urinary Tract Symptoms/physiopathology* ; Male ; Middle Aged ; Prostate/physiopathology* ; Prostatectomy ; Prostatic Neoplasms/surgery* ; Risk Factors ; Severity of Illness Index ; Surveys and Questionnaires
OBJECTIVE: To investigate the associations between prostate elasticity and lower urinary tract symptoms (LUTS). METHODS: From August 2009 to December 2009, 48 patients with no history of neoadjuvant therapy or previous prostate surgery who underwent robot-assisted radical prostatectomy were included in this study. A novel palpation system was used to measure the tissue elasticity of the prostate specimens. The elasticity of the prostate was defined as the mean elastic modulus (kilopascals [kPa]) of 21 sites from the posterior surface of prostate. All patients completed an International Prostate Symptoms Score questionnaire before surgery, and LUTS was defined as an International Prostate Symptoms Score total of ≥8. Significant voiding symptoms were identified by a score of ≥5 on the basis of patient responses to 4 questions (Q1, Q3, Q5, and Q6), and storage symptoms were identified by a score ≥4 on the basis of patient responses to 3 questions (Q2, Q4, and Q7). RESULTS: The median elastic modulus of the prostate was 20.8 kPa (interquartile range 15.6-22.9), and the LUTS incidences and voiding symptoms were significantly higher in patients with an elastic modulus >20 kPa. The multivariate logistic regression results indicated that a higher elastic modulus (as a continuous variable) was independently associated with voiding symptoms (odds ratio 1.18, P = .038) after controlling for age and prostate volume. However, the elastic modulus was not independently associated with LUTS or storage symptoms. CONCLUSION: Patients with greater prostate stiffness are more likely to develop LUTS. Specifically, prostate elasticity was independently associated with voiding symptoms.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Hyun(김광현)
Kim, Jang Hwan(김장환) ORCID logo https://orcid.org/0000-0002-9056-7072
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Lim, Sey Kiat(임세이캣)
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
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