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Resveratrol Inhibits Phenotype Modulation by Platelet Derived Growth Factor-bb in Rat Aortic Smooth Muscle Cells

Authors
 Mi Hee Lee  ;  Byeong-Ju Kwon  ;  Hyok Jin Seo  ;  Kyeong Eun Yoo  ;  Min Sung Kim  ;  Min-Ah Koo  ;  Jong-Chul Park 
Citation
 OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, Vol.2014 : 572430, 2014 
Journal Title
 OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 
ISSN
 1942-0900 
Issue Date
2014
MeSH
Actin Cytoskeleton/drug effects ; Actin Cytoskeleton/metabolism ; Actins/metabolism ; Animals ; Aorta/cytology* ; Cell Dedifferentiation/drug effects ; Cell Proliferation/drug effects ; Cell Shape/drug effects ; Myocytes, Smooth Muscle/cytology* ; Phenotype ; Proto-Oncogene Proteins c-sis/pharmacology* ; Rats ; Signal Transduction/drug effects ; Stilbenes/pharmacology*
Abstract
Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of platelet derived growth factor-bb (PDGF-bb) in rat aortic vascular smooth muscle cells (RAOSMCs). Treatment of RAOSMCs with resveratrol showed dose-dependent inhibition of PDGF-bb-stimulated proliferation. Resveratrol treatment inhibited this phenotype change and disassembly of actin filaments and maintained the expression of contractile phenotype-related proteins such as calponin and smooth muscle actin-alpha in comparison with only PDGF-bb stimulated RAOSMC. Although PDGF stimulation elicited strong and detectable Akt and mTOR phosphorylations lasting for several hours, Akt activation was much weaker when PDGF was used with resveratrol. In contrast, resveratrol only slightly inhibited phosphorylations of 42/44 MAPK and p38 MAPK. In conclusion, RAOSMC dedifferentiation, phenotype, and proliferation rate were inhibited by resveratrol via interruption of the balance of Akt, 42/44MAPK, and p38MAPK pathway activation stimulated by PDGF-bb.
Files in This Item:
T201400651.pdf Download
DOI
10.1155/2014/572430
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Koo, Min-Ah(구민아) ORCID logo https://orcid.org/0000-0002-8671-1131
Kwon, Byeong-Ju(권병주) ORCID logo https://orcid.org/0000-0001-9916-0546
Kim, Min Sung(김민성)
You, Kyung Eun(류경은)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Seo, Hyok Jin(서혁진)
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98300
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