214 205

Cited 8 times in

Resveratrol Inhibits Phenotype Modulation by Platelet Derived Growth Factor-bb in Rat Aortic Smooth Muscle Cells

Authors
 Mi Hee Lee  ;  Byeong-Ju Kwon  ;  Hyok Jin Seo  ;  Kyeong Eun Yoo  ;  Min Sung Kim  ;  Min-Ah Koo  ;  Jong-Chul Park 
Citation
 Oxidative Medicine and Cellular Longevity, Vol.2014 : 572430-572430, 2014 
Journal Title
 Oxidative Medicine and Cellular Longevity 
ISSN
 1942-0900 
Issue Date
2014
Abstract
Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of platelet derived growth factor-bb (PDGF-bb) in rat aortic vascular smooth muscle cells (RAOSMCs). Treatment of RAOSMCs with resveratrol showed dose-dependent inhibition of PDGF-bb-stimulated proliferation. Resveratrol treatment inhibited this phenotype change and disassembly of actin filaments and maintained the expression of contractile phenotype-related proteins such as calponin and smooth muscle actin-alpha in comparison with only PDGF-bb stimulated RAOSMC. Although PDGF stimulation elicited strong and detectable Akt and mTOR phosphorylations lasting for several hours, Akt activation was much weaker when PDGF was used with resveratrol. In contrast, resveratrol only slightly inhibited phosphorylations of 42/44 MAPK and p38 MAPK. In conclusion, RAOSMC dedifferentiation, phenotype, and proliferation rate were inhibited by resveratrol via interruption of the balance of Akt, 42/44MAPK, and p38MAPK pathway activation stimulated by PDGF-bb.
Files in This Item:
T201400651.pdf Download
DOI
10.1155/2014/572430
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
구민아(Koo, Min-Ah) ORCID logo https://orcid.org/0000-0002-8671-1131
권병주(Kwon, Byeong-Ju) ORCID logo https://orcid.org/0000-0001-9916-0546
김민성(Kim, Min Sung)
류경은(You, Kyung Eun)
박종철(Park, Jong Chul) ORCID logo https://orcid.org/0000-0003-0083-5991
서혁진(Seo, Hyok Jin)
이미희(Lee, Mi Hee) ORCID logo https://orcid.org/0000-0002-9630-7044
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98300
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse