353 252

Cited 18 times in

Targeted therapy in gastric cancer: Personalizing cancer treatment based on patient genome

 Sun Min Lim  ;  Jae Yun Lim  ;  Jae Yong Cho 
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.20(8) : 2042-2050, 2014 
Journal Title
Issue Date
Epithelial-Mesenchymal Transition ; Gene Expression Profiling ; Genome, Human ; Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; MicroRNAs/metabolism ; Oligonucleotide Array Sequence Analysis ; Phosphatidylinositol 3-Kinases/metabolism ; Precision Medicine/methods* ; Receptor, Epidermal Growth Factor/metabolism ; Sequence Analysis, RNA ; Stomach Neoplasms/genetics* ; Stomach Neoplasms/therapy* ; Treatment Outcome
Biomarker ; Gastric cancer ; Microarray ; Sequencing ; Targeted therapy
Gastric cancer is the second leading cause of cancer-related deaths worldwide. Conventional cytotoxic chemotherapy has limited efficacy for metastatic gastric cancer, with an overall survival of approximately ten months. Recent advances in high-throughput technologies have enabled the implementation of personalized cancer therapy for high-risk patients. The use of such high-throughput technologies, including microarray and next generation sequencing, have promoted the discovery of novel targets that offer new treatment strategies for patients lacking other therapeutic options. Many molecular pathways are currently under investigation as therapeutic targets in gastric cancer, including those related to the epidermal growth factor receptor family, the mesenchymal-epithelial transition factor axis, and the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin factors. Advances in molecular diagnostic tools further support the discovery of new molecular targets. Limitations exist, however; not all patients can be tested for biomarkers, and numerous challenges hamper implementation of targeted therapy in clinical settings. Indeed, the scale of tumor genomic profiling is rapidly outpacing our ability to appropriately synthesize all the information in order to optimally refine patient care. Therefore, clinicians must continue to educate themselves regarding new tools and frameworks, and to utilize multidisciplinary team science, comprised of oncologists, geneticists, pathologists, biologists and bioinformaticians, to successfully implement this genomic approach therapeutically.
Files in This Item:
T201400475.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lim, Sun Min(임선민)
Lim, Jae Yun(임재윤)
Cho, Jae Yong(조재용) ORCID logo https://orcid.org/0000-0002-0926-1819
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.