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Cited 19 times in

Targeted therapy in gastric cancer: Personalizing cancer treatment based on patient genome

DC Field Value Language
dc.contributor.author임선민-
dc.contributor.author임재윤-
dc.contributor.author조재용-
dc.date.accessioned2015-01-06T16:30:10Z-
dc.date.available2015-01-06T16:30:10Z-
dc.date.issued2014-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98226-
dc.description.abstractGastric cancer is the second leading cause of cancer-related deaths worldwide. Conventional cytotoxic chemotherapy has limited efficacy for metastatic gastric cancer, with an overall survival of approximately ten months. Recent advances in high-throughput technologies have enabled the implementation of personalized cancer therapy for high-risk patients. The use of such high-throughput technologies, including microarray and next generation sequencing, have promoted the discovery of novel targets that offer new treatment strategies for patients lacking other therapeutic options. Many molecular pathways are currently under investigation as therapeutic targets in gastric cancer, including those related to the epidermal growth factor receptor family, the mesenchymal-epithelial transition factor axis, and the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin factors. Advances in molecular diagnostic tools further support the discovery of new molecular targets. Limitations exist, however; not all patients can be tested for biomarkers, and numerous challenges hamper implementation of targeted therapy in clinical settings. Indeed, the scale of tumor genomic profiling is rapidly outpacing our ability to appropriately synthesize all the information in order to optimally refine patient care. Therefore, clinicians must continue to educate themselves regarding new tools and frameworks, and to utilize multidisciplinary team science, comprised of oncologists, geneticists, pathologists, biologists and bioinformaticians, to successfully implement this genomic approach therapeutically.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2042~2050-
dc.relation.isPartOfWORLD JOURNAL OF GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHEpithelial-Mesenchymal Transition-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHGenome, Human-
dc.subject.MESHGenomics-
dc.subject.MESHHigh-Throughput Nucleotide Sequencing-
dc.subject.MESHHumans-
dc.subject.MESHMicroRNAs/metabolism-
dc.subject.MESHOligonucleotide Array Sequence Analysis-
dc.subject.MESHPhosphatidylinositol 3-Kinases/metabolism-
dc.subject.MESHPrecision Medicine/methods*-
dc.subject.MESHReceptor, Epidermal Growth Factor/metabolism-
dc.subject.MESHSequence Analysis, RNA-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/therapy*-
dc.subject.MESHTreatment Outcome-
dc.titleTargeted therapy in gastric cancer: Personalizing cancer treatment based on patient genome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSun Min Lim-
dc.contributor.googleauthorJae Yun Lim-
dc.contributor.googleauthorJae Yong Cho-
dc.identifier.doi10.3748/wjg.v20.i8.2042-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03369-
dc.contributor.localIdA03398-
dc.contributor.localIdA03899-
dc.relation.journalcodeJ02795-
dc.identifier.eissn2219-2840-
dc.identifier.pmid24587678-
dc.subject.keywordBiomarker-
dc.subject.keywordGastric cancer-
dc.subject.keywordMicroarray-
dc.subject.keywordSequencing-
dc.subject.keywordTargeted therapy-
dc.contributor.alternativeNameLim, Sun Min-
dc.contributor.alternativeNameLim, Jae Yun-
dc.contributor.alternativeNameCho, Jae Yong-
dc.contributor.affiliatedAuthorLim, Sun Min-
dc.contributor.affiliatedAuthorLim, Jae Yun-
dc.contributor.affiliatedAuthorCho, Jae Yong-
dc.citation.volume20-
dc.citation.number8-
dc.citation.startPage2042-
dc.citation.endPage2050-
dc.identifier.bibliographicCitationWORLD JOURNAL OF GASTROENTEROLOGY, Vol.20(8) : 2042-2050, 2014-
dc.identifier.rimsid50730-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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