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Changing clinical expression of Behçet disease in Korea during three decades (1983–2012): chronological analysis of 3674 hospital-based patients

 D.Y. Kim  ;  M.J. Choi  ;  S. Cho  ;  D.W. Kim  ;  D. Bang 
 British Journal of Dermatology, Vol.170(2) : 458-461, 2014 
Journal Title
 British Journal of Dermatology 
Issue Date
Adolescent ; Adult ; Age Distribution ; Behcet Syndrome/epidemiology* ; Behcet Syndrome/therapy ; Central Nervous System Diseases/epidemiology ; Central Nervous System Diseases/therapy ; Child ; Child, Preschool ; Female ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/therapy ; Genital Diseases, Female/epidemiology ; Genital Diseases, Female/therapy ; Genital Diseases, Male/epidemiology ; Genital Diseases, Male/therapy ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Prevalence ; Republic of Korea/epidemiology ; Retrospective Studies ; Sex Distribution ; Time Factors ; Young Adult
BACKGROUND: Behçet disease (BD) is a chronic multisystemic vasculitis affecting blood vessels of any calibre or type. Recent evidence suggests that the clinical expression of BD is lessening. OBJECTIVES: To examine the clinical expression of BD in Korea during the past three decades via a large patient registry. METHODS: Initial manifestations of patients with BD seen at a tertiary referral hospital between 1983 and 2012 were reviewed retrospectively, stratifying patients by decade to compare epidemiological data and cardinal symptoms. RESULTS: In total 3674 patients with BD were reviewed. Significant proportional declines occurred with respect to male sex, complete type BD and major presenting features (genital ulcers, ocular involvement and skin lesions), whereas the mean patient age rose progressively, as did the frequencies of joint, gastrointestinal and central nervous system manifestations (all P < 0·0001). CONCLUSIONS: During the past three decades, clinical expression of BD in Korea has changed, resulting in fewer instances of complete type disease, declining male propensity, and shifting patterns of organ involvement.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영) ORCID logo https://orcid.org/0000-0002-0194-9854
Kim, Dong Wook(김동욱)
Bang, Dong Sik(방동식)
Cho, Su Hyun(조수현)
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