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Comparison of the Haas and the Oxford classifications for prediction of renal outcome in patients with IgA nephropathy.

Authors
 Kyoung Sook Park  ;  Seung Hyeok Han  ;  Jeong Hae Kie  ;  Ki Heon Nam  ;  Mi Jung Lee  ;  Beom Jin Lim  ;  Young Eun Kwon  ;  Yung Ly Kim  ;  Seong Yeong An  ;  Chan Ho Kim  ;  Fa Mee Doh  ;  Hyang Mo Koo  ;  Hyung Jung Oh  ;  Shin-Wook Kang  ;  Kyu Hun Choi  ;  Hyeon Joo Jeong  ;  Tae-Hyun Yoo 
Citation
 Human Pathology, Vol.45(2) : 236-243, 2014 
Journal Title
 Human Pathology 
ISSN
 0046-8177 
Issue Date
2014
Abstract
Pathologic features can provide valuable information for determining prognosis in IgA nephropathy (IgAN). However, it is uncertain whether the Oxford classification, a new classification of IgAN, can predict renal outcome better than previous ones. We conducted a retrospective cohort study in 500 patients with biopsy-proven IgAN between January 2002 and December 2010 to compare the ability of the Haas and the Oxford classifications to predict renal outcome. Primary outcome was a doubling of the baseline serum creatinine concentration (D-SCr). During a mean follow-up of 68 months, 52 (10.4%) and 35 (7.0%) developed D-SCr and end-stage renal disease, respectively. There were graded increases in the development of D-SCr in the higher Haas classes. In addition, the primary endpoint of D-SCr occurred more in patients with the Oxford M and T lesions than those without such lesions. In multivariate Cox regression analyses, the Haas class V (HR, 12.19; P=.002) and the Oxford T1 (hazard ratio [HR], 6.68; P<.001) and T2 (HR, 12.16; P<.001) lesions were independently associated with an increased risk of reaching D-SCr. Harrell's C index of each multivariate model with the Haas and the Oxford classification was 0.867 (P=.015) and 0.881 (P=.004), respectively. This was significantly higher than that of model with clinical factors only (C=0.819). However, there was no difference in C-statistics between the 2 models with the Haas and the Oxford classifications (P=.348). This study suggests that the Haas and the Oxford classifications are comparable in predicting progression of IgAN.
Full Text
http://www.sciencedirect.com/science/article/pii/S0046817713003766
DOI
10.1016/j.humpath.2013.08.019
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
강신욱(Kang, Shin Wook) ORCID logo https://orcid.org/0000-0002-5677-4756
구향모(Koo, Hyang Mo)
권영은(Kwon, Young Eun)
기정혜(Kie, Jeong Hae)
김영리(Kim, Yung Ly)
김찬호(Kim, Chan Ho)
남기헌(Nam, Ki Heon) ORCID logo https://orcid.org/0000-0001-7312-7027
도화미(Doh, Fa Mee) ORCID logo https://orcid.org/0000-0002-4780-6728
박경숙(Park, Kyoung Sook)
안성영(An, Seong Yeong)
오형중(Oh, Hyung Jung)
유태현(Yoo, Tae Hyun) ORCID logo https://orcid.org/0000-0002-9183-4507
이미정(Lee, Mi Jung)
임범진(Lim, Beom Jin) ORCID logo https://orcid.org/0000-0003-2856-0133
정현주(Jeong, Hyeon Joo) ORCID logo https://orcid.org/0000-0002-9695-1227
최규헌(Choi, Kyu Hun) ORCID logo https://orcid.org/0000-0003-0095-9011
한승혁(Han, Seung Hyeok) ORCID logo https://orcid.org/0000-0001-7923-5635
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98063
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