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The Chronicity of Tonsillitis Is Significantly Correlated with an Increase in an LTi Cell Portion

 Jung Hyun Chang  ;  Soochan Kim  ;  Jihye Koo  ;  Peter J. L. Lane  ;  Sun Och Yoon  ;  Ah Young Park  ;  Kyung-Su Kim  ;  Mi-Yeon Kim 
 INFLAMMATION, Vol.37(1) : 132-141, 2014 
Journal Title
Issue Date
Antigens, Differentiation/biosynthesis ; CD3 Complex/metabolism ; CD4-Positive T-Lymphocytes/immunology* ; CD56 Antigen/metabolism ; Humans ; Ibuprofen/therapeutic use ; Immunologic Memory/immunology* ; Inflammation/immunology ; Interleukin-7 Receptor alpha Subunit/metabolism ; Interleukins/biosynthesis* ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; OX40 Ligand/biosynthesis* ; Palatine Tonsil/cytology ; Palatine Tonsil/immunology ; Proto-Oncogene Proteins c-kit/metabolism ; Tonsillitis/drug therapy ; Tonsillitis/immunology*
lymphoid tissue inducer ; CD4 T cell ; tonsillitis ; OX40L ; IL-22
The current study explored the relationship between lymphoid tissue inducer (LTi) cells and patients’ clinical and immunological status. LTi cells are critical for lymphoid tissue development and maintenance of CD4 T cell-dependent immune responses. The percentage of CD117+CD3−CD56−CD127+ RORγ+ LTi cells isolated from human tonsils was determined and correlated with changes in other immune subsets and clinical factors. We found that the portion of LTi and CD4 T cells was significantly increased in chronic tonsillitis compared to non-inflamed tonsils. Additionally, the expression of OX40 by memory CD4 T cells and OX40 ligand (OX40L) and interleukin (IL)-22 by LTi cells was higher in chronically inflamed tonsils. The treatment for tonsillitis with ibuprofen did not alter LTi cell viability and the expression of OX40L and IL-22. These results demonstrate that during chronic inflammation, LTi cells are increased and express higher levels of OX40L and IL-22, and this is correlated with an increase in memory CD4 T cells.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
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