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The Chronicity of Tonsillitis Is Significantly Correlated with an Increase in an LTi Cell Portion

Authors
 Jung Hyun Chang  ;  Soochan Kim  ;  Jihye Koo  ;  Peter J. L. Lane  ;  Sun Och Yoon  ;  Ah Young Park  ;  Kyung-Su Kim  ;  Mi-Yeon Kim 
Citation
 Inflammation, Vol.37(1) : 132-141, 2014 
Journal Title
 Inflammation 
ISSN
 0360-3997 
Issue Date
2014
Abstract
The current study explored the relationship between lymphoid tissue inducer (LTi) cells and patients’ clinical and immunological status. LTi cells are critical for lymphoid tissue development and maintenance of CD4 T cell-dependent immune responses. The percentage of CD117+CD3−CD56−CD127+ RORγ+ LTi cells isolated from human tonsils was determined and correlated with changes in other immune subsets and clinical factors. We found that the portion of LTi and CD4 T cells was significantly increased in chronic tonsillitis compared to non-inflamed tonsils. Additionally, the expression of OX40 by memory CD4 T cells and OX40 ligand (OX40L) and interleukin (IL)-22 by LTi cells was higher in chronically inflamed tonsils. The treatment for tonsillitis with ibuprofen did not alter LTi cell viability and the expression of OX40L and IL-22. These results demonstrate that during chronic inflammation, LTi cells are increased and express higher levels of OX40L and IL-22, and this is correlated with an increase in memory CD4 T cells.
Full Text
http://link.springer.com/article/10.1007%2Fs10753-013-9721-0
DOI
10.1007/s10753-013-9721-0
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실)
Yonsei Authors
김경수(Kim, Kyung Su) ORCID logo https://orcid.org/0000-0003-1460-0640
윤선옥(Yoon, Sun Och) ORCID logo https://orcid.org/0000-0002-5115-1402
장정현(Chang, Jung Hyun)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98005
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