Cited 2 times in
The Chronicity of Tonsillitis Is Significantly Correlated with an Increase in an LTi Cell Portion
DC Field | Value | Language |
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dc.contributor.author | 김경수 | - |
dc.contributor.author | 윤선옥 | - |
dc.date.accessioned | 2015-01-06T16:23:02Z | - |
dc.date.available | 2015-01-06T16:23:02Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0360-3997 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98005 | - |
dc.description.abstract | The current study explored the relationship between lymphoid tissue inducer (LTi) cells and patients’ clinical and immunological status. LTi cells are critical for lymphoid tissue development and maintenance of CD4 T cell-dependent immune responses. The percentage of CD117+CD3−CD56−CD127+ RORγ+ LTi cells isolated from human tonsils was determined and correlated with changes in other immune subsets and clinical factors. We found that the portion of LTi and CD4 T cells was significantly increased in chronic tonsillitis compared to non-inflamed tonsils. Additionally, the expression of OX40 by memory CD4 T cells and OX40 ligand (OX40L) and interleukin (IL)-22 by LTi cells was higher in chronically inflamed tonsils. The treatment for tonsillitis with ibuprofen did not alter LTi cell viability and the expression of OX40L and IL-22. These results demonstrate that during chronic inflammation, LTi cells are increased and express higher levels of OX40L and IL-22, and this is correlated with an increase in memory CD4 T cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INFLAMMATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antigens, Differentiation/biosynthesis | - |
dc.subject.MESH | CD3 Complex/metabolism | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/immunology* | - |
dc.subject.MESH | CD56 Antigen/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ibuprofen/therapeutic use | - |
dc.subject.MESH | Immunologic Memory/immunology* | - |
dc.subject.MESH | Inflammation/immunology | - |
dc.subject.MESH | Interleukin-7 Receptor alpha Subunit/metabolism | - |
dc.subject.MESH | Interleukins/biosynthesis* | - |
dc.subject.MESH | Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism | - |
dc.subject.MESH | OX40 Ligand/biosynthesis* | - |
dc.subject.MESH | Palatine Tonsil/cytology | - |
dc.subject.MESH | Palatine Tonsil/immunology | - |
dc.subject.MESH | Proto-Oncogene Proteins c-kit/metabolism | - |
dc.subject.MESH | Tonsillitis/drug therapy | - |
dc.subject.MESH | Tonsillitis/immunology* | - |
dc.title | The Chronicity of Tonsillitis Is Significantly Correlated with an Increase in an LTi Cell Portion | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Jung Hyun Chang | - |
dc.contributor.googleauthor | Soochan Kim | - |
dc.contributor.googleauthor | Jihye Koo | - |
dc.contributor.googleauthor | Peter J. L. Lane | - |
dc.contributor.googleauthor | Sun Och Yoon | - |
dc.contributor.googleauthor | Ah Young Park | - |
dc.contributor.googleauthor | Kyung-Su Kim | - |
dc.contributor.googleauthor | Mi-Yeon Kim | - |
dc.identifier.doi | 10.1007/s10753-013-9721-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00298 | - |
dc.contributor.localId | A02566 | - |
dc.contributor.localId | A03468 | - |
dc.relation.journalcode | J01058 | - |
dc.identifier.eissn | 1573-2576 | - |
dc.identifier.pmid | 24022597 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10753-013-9721-0 | - |
dc.subject.keyword | lymphoid tissue inducer | - |
dc.subject.keyword | CD4 T cell | - |
dc.subject.keyword | tonsillitis | - |
dc.subject.keyword | OX40L | - |
dc.subject.keyword | IL-22 | - |
dc.contributor.alternativeName | Kim, Kyung Su | - |
dc.contributor.alternativeName | Yoon, Sun Och | - |
dc.contributor.alternativeName | Chang, Jung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Su | - |
dc.contributor.affiliatedAuthor | Yoon, Sun Och | - |
dc.contributor.affiliatedAuthor | Chang, Jung Hyun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 132 | - |
dc.citation.endPage | 141 | - |
dc.identifier.bibliographicCitation | INFLAMMATION, Vol.37(1) : 132-141, 2014 | - |
dc.identifier.rimsid | 54326 | - |
dc.type.rims | ART | - |
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