Cited 28 times in
Aptamer-conjugated gold nanorod for photothermal ablation of epidermal growth factor receptor-overexpressed epithelial cancer
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-01-06T16:21:14Z | - |
dc.date.available | 2015-01-06T16:21:14Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1083-3668 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97950 | - |
dc.description.abstract | Biomarker-specific photothermal nanoparticles that can efficiently sense markers that are overexpressed in distinguished adenocarcinomas have attracted much interest in an aspect of efficacy increase of cancer treatment. We demonstrated a promising prospect of a smart photothermal therapy agent employing anti-epidermal growth factor receptor aptamer (AptEGFR)-conjugated polyethylene glycol (PEG) layted gold nanorods (AptEGFR-PGNRs). The cetyltrimethylammonium bromide bilayer on GNRs was replaced with heterobifunctional PEG (COOH-PEG-SH) not only to serve as a biocompatible stabilizer and but also to conjugate AptEGFR. Subsequently, to direct photothermal therapy agent toward epithelial cancer cells, the carboxylated PEGylated GNRs (PGNRs) were further functionalized with AptEGFR using carbodiimide chemistry. Then, to assess the potential as biomarker-specific photothermal therapy agent of synthesized AptEGFR-PGNRs, the optical properties, biocompatibility, colloidal stability, binding affinity, and epicellial cancer cell killing efficacy in vitro/in vivo under near-infrared laser irradiation were investigated. As a result, AptEGFR-PGNRs exhibit excellent tumor targeting ability and feasibility of effective photothermal ablation cancer therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF BIOMEDICAL OPTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Aptamers, Nucleotide/chemistry* | - |
dc.subject.MESH | Aptamers, Nucleotide/genetics | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Gold/chemistry* | - |
dc.subject.MESH | Gold/pharmacology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Nanotubes/chemistry* | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/metabolism | - |
dc.subject.MESH | Phototherapy/methods* | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/genetics* | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/metabolism | - |
dc.subject.MESH | Xenograft Model Antitumor Assays | - |
dc.title | Aptamer-conjugated gold nanorod for photothermal ablation of epidermal growth factor receptor-overexpressed epithelial cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Jihye Choi | - |
dc.contributor.googleauthor | Yeonji Park | - |
dc.contributor.googleauthor | Eun Bi Choi | - |
dc.contributor.googleauthor | Hyun-Ouk Kim | - |
dc.contributor.googleauthor | Dong Joo Kim | - |
dc.contributor.googleauthor | Yoochan Hong | - |
dc.contributor.googleauthor | Sung-Ho Ryu | - |
dc.contributor.googleauthor | Jung Hwan Lee | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1117/1.JBO.19.5.051203 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J01269 | - |
dc.identifier.eissn | 1560-2281 | - |
dc.identifier.pmid | 24297058 | - |
dc.identifier.url | http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1787520 | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 21203 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL OPTICS, Vol.19(5) : 21203, 2014 | - |
dc.identifier.rimsid | 53446 | - |
dc.type.rims | ART | - |
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