Cited 18 times in
Differentiation of Antigen-Specific T Cells with Limited Functional Capacity during Mycobacterium tuberculosis Infection
DC Field | Value | Language |
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dc.contributor.author | 구선화 | - |
dc.contributor.author | 신성재 | - |
dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2015-01-06T16:20:37Z | - |
dc.date.available | 2015-01-06T16:20:37Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0019-9567 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97932 | - |
dc.description.abstract | Despite the generation of Mycobacterium tuberculosis-specific T cell immune responses during the course of infection, only 5 to 10% of exposed individuals develop active disease, while others develop a latent infection. This phenomenon suggests defective M. tuberculosis-specific immunity, which necessitates more careful characterization of M. tuberculosis-specific T cell responses. Here, we longitudinally analyzed the phenotypes and functions of M. tuberculosis-specific T cells. In contrast to the functional exhaustion of T cells observed after chronic infection, M. tuberculosis-specific CD8+ T cells differentiated into either effector (CD127lo CD62Llo) or effector memory (CD127hi CD62Llo) cells, but not central memory cells (CD127hi CD62Lhi), with low programmed death 1 (PD-1) expression, even in the presence of high levels of bacteria. Additionally, M. tuberculosis-specific CD8+ and CD4+ T cells produced substantial levels of tumor necrosis factor alpha (TNF-α) and gamma interferon (IFN-γ), but not interleukin 2 (IL-2), upon in vitro restimulation. Among M. tuberculosis-specific CD8+ T cells, CD127hi effector memory cells displayed slower ongoing turnover but greater survival potential. In addition, these cells produced more IFN-γ and TNF-α and displayed lytic activity upon antigen stimulation. However, the effector function of M. tuberculosis-specific CD8+ CD127hi effector memory T cells was inferior to that of canonical CD8+ CD127hi memory T cells generated after acute lymphocytic choriomeningitis virus infection. Collectively, our data demonstrate that M. tuberculosis-specific T cells can differentiate into memory T cells during the course of M. tuberculosis infection independent of the bacterial burden but with limited functionality. These results provide a framework for further understanding the mechanisms of M. tuberculosis infection that can be used to develop more effective vaccines. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INFECTION AND IMMUNITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, Bacterial/immunology | - |
dc.subject.MESH | Antigens, Differentiation/immunology | - |
dc.subject.MESH | Bacterial Load | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/immunology* | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/immunology* | - |
dc.subject.MESH | Cell Differentiation/immunology | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Immunity, Cellular/immunology | - |
dc.subject.MESH | Immunologic Memory/physiology | - |
dc.subject.MESH | Interferon-gamma/metabolism | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology* | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | T-Lymphocytes, Helper-Inducer/immunology | - |
dc.subject.MESH | Tuberculosis/immunology* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism | - |
dc.title | Differentiation of Antigen-Specific T Cells with Limited Functional Capacity during Mycobacterium tuberculosis Infection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Yun Hee Jeong | - |
dc.contributor.googleauthor | Bo-Young Jeon | - |
dc.contributor.googleauthor | Sun-Hwa Gu | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Jun Chang | - |
dc.contributor.googleauthor | Sang-Jun Ha | - |
dc.identifier.doi | 10.1128/IAI.00480-13 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00195 | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A02113 | - |
dc.relation.journalcode | J01055 | - |
dc.identifier.eissn | 1098-5522 | - |
dc.identifier.pmid | 24126533 | - |
dc.identifier.url | http://iai.asm.org/content/82/1/132.long | - |
dc.contributor.alternativeName | Gu, Sun Hwa | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Gu, Sun Hwa | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 82 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 132 | - |
dc.citation.endPage | 139 | - |
dc.identifier.bibliographicCitation | INFECTION AND IMMUNITY, Vol.82(1) : 132-139, 2014 | - |
dc.identifier.rimsid | 53438 | - |
dc.type.rims | ART | - |
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