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Urine melatonin levels are inversely associated with sarcopenia in postmenopausal women

 Jee-Yon Lee  ;  Jung-Ha Kim  ;  Duk-Chul Lee 
 Menopause - the Journal of the North American Menopause Society, Vol.21(1) : 39-44, 2014 
Journal Title
 Menopause - the Journal of the North American Menopause Society 
Issue Date
Absorptiometry, Photon ; Biomarkers/urine ; Cross-Sectional Studies ; Female ; Humans ; Melatonin/analogs & derivatives* ; Melatonin/physiology ; Melatonin/urine* ; Middle Aged ; Postmenopause/urine* ; Republic of Korea ; Sarcopenia/diagnostic imaging ; Sarcopenia/urine*
Sarcopenia ; Melatonin ; 6-Sulfatoxymelatonin
OBJECTIVE: Mainly secreted in the pineal gland, melatonin is a neurohormone that has versatile functions, including cellular protection. Decreased melatonin levels are associated with the aging process and age-related conditions. Melatonin may be associated with sarcopenia because it is one of the most common age-related diseases and because disrupted cellular vitality in skeletal muscle is known to be involved in its pathogenesis. Therefore, we investigated the relationship between first-morning-urine 6-sulfatoxymelatonin (aMT6s) levels and sarcopenia in Korean postmenopausal women. METHODS: Seventy-eight Korean postmenopausal women participated. Biomarkers of metabolic risk factors, along with the presence of sarcopenia, were assessed using dual-energy x-ray absorptiometry. Urine aMT6s levels were measured using enzyme-linked immunosorbent assay. RESULTS: The prevalence of sarcopenia increased significantly with increasing aMT6s quartiles. Furthermore, multivariate logistic regression analysis showed that the fourth aMT6s quartile was associated with sarcopenia, with an adjusted odds ratio of 0.13 (95% CI, 0.03-0.70; P = 0.02). CONCLUSIONS: Our study shows an inverse association between urine melatonin and sarcopenia, suggesting that melatonin may have a protective role in the pathophysiology of sarcopenia. Further studies are required to better understand the clinical significance of our findings.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Jee Yon(이지연)
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