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편광 민감 광결맞음 단층 촬영 장치를 이용한 자궁경부의 조기 진단(A Preliminary Study)

Other Titles
 Early-Stage Diagnosis of Cervix using the Polarization Sensitive Optical Coherence Tomography(A Preliminary Study) 
Authors
 강진호  ;  이상원  ;  조남훈  ;  김영태  ;  윤보성  ;  김법민  ;  강문식  ;  유지영 
Citation
 Korean Journal of Optics and Photonics (한국광학회지), Vol.18(5) : 367-372, 2007 
Journal Title
 Korean Journal of Optics and Photonics (한국광학회지) 
ISSN
 1225-6285 
Issue Date
2007
Abstract
Cervical dysplasia induces morphologic changes in the cervical epithelium which involve changes in the nuclear/cytoplasmic (N/C) ratio. Since the nucleus is one of the significant scattering sources, the N/C ratio change reflects the degree of circular polarization (DOCP) with the depth of signals. Therefore, we used the polarization-sensitive OCT (PS-OCT) technique to measure the polarization changes caused by scattering. Cervical tissues were obtained from a high-grade squamous intraepithelial lesion (H-SIL) of one woman and from low normal women. We obtained the mean of the DOCP as a function of depth in the cervix and quantified the change ratio of the DOCP using slopes that were determined by linear fits in the epithelium layer. We found that DOCP of H-SIL decayed faster than that of normal tissue because of the higher scattering in H-SIL as expected. This result indicates that the PS-OCT system might be useful in measurements of change ratio of DOCP with depth for screening of cervical dysplasia.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Yoo, Ji Yeong(유지영)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97877
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