Purpose: Laparoscopic wedge resection (LWR) is replacing open wedge resection (OWR) as the standard surgical treatment for gastric submucosal tumors. However, few scientific comparisons exist as to whether LWR or OWR is better in terms of postoperative outcomes. This study was performed to compare these two treatment modalities for the treatment of gastric submucosal tumors by evaluating the postoperative outcomes. Methods: Between 1993 and 2004, 112 patients with a gastric submucosal tumor had undergone either LWR (n=42) or OWR (n=70). Their medical records were retrospectively reviewed with regard to tumor size, operative time, time to first flatus, postoperative hospital stay and analgesics use. Results: The demographics and tumor characteristics of the patients were similar in both groups. Four (9%) cases in the LWR group were converted to an open procedure. The mean operation time was longer in the LWR than the OWR group (100.6 vs. 84.3 min)(P=0.015). The time to first flatus (1.8⁑0.1 vs. 3.3⁑0.1 days, respectively, P<0.0001) and soft diet intake (3.5⁑0.3 vs. 6.0⁑0.2 days, respectively, P<0.0001) were shorter in the LWR compared to the OWR group. The postoperative hospital stay was significantly shorter in the LWR than in the OWR group (5.3⁑0.6 vs. 8.5⁑0.2 days) (P<0.0001). The number of analgesics uses (2.7⁑0.4 times) in the LWR was less than that in the OWR group (2.7⁑0.4 vs. 4.1⁑0.5 times)(P=0.0056). Conclusion: Laparoscopic wedge resection of a gastric submucosal tumor was superior to open wedge resection in terms of the postoperative outcomes. Laparoscopic wedge resection could be considered the first-line treatment for gastric submucosal tumors.