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투석을 시행 받고 있는 말기 신부전증 환자에서 위장관 출혈의 위험인자

Other Titles
 Risk factors of gastrointestinal bleeding for end-stage renal disease patients 
Authors
 오형중  ;  김승준  ;  강신욱  ;  한대석  ;  최훈영  ;  이정은  ;  한승혁  ;  문성진  ;  이태희  ;  김동기  ;  문지애  ;  구남수  ;  이한성  ;  유동은  ;  박선영 
Citation
 Korean Journal of Medicine, Vol.72(6) : 616-624, 2007 
Journal Title
 Korean Journal of Medicine 
ISSN
 1738-9364 
Issue Date
2007
Abstract
Background: Gastrointestinal bleeding (GIB) is not a rare complication in end stage renal disease (ESRD) patients on dialysis and the occurrence of GIB has also been associated with higher morbidity and mortality rates. However, reasons for the high incidence of GIB are not clear. This retrospective study was undertaken not only to analyze the clinical features of GIB but also to elucidate the independent risk factors for GIB in Korean ESRD patients. Methods: One hundred thirty ESRD patients on dialysis at the Severance Hospital of Yonsei University College of Medicine from January 2000 to December 2005 were included in the study. The patients were divided into two groups: 65 patients with GIB (the GIB group) and 65 age-, sex-, and dialysis modality-matched patients without GIB (the C group). Clinical characteristics, medications, and laboratory findings were compared between the two groups. Results: Compared to the C group, congestive heart failure (40.0% vs. 21.5%, p<0.05), coronary arterial occlusive disease (CAOD) (32.3% vs. 4.6%, p<0.005), and nonsteroidal anti-inflammatory drug (NSAID) use (18.4% vs. 1.5%, p<0.01) were significantly more common in the GIB group. The baseline serum albumin levels were significantly lower in the GIB group than in the C group (2.53±0.67 g/dL vs. 3.56±0.63 g/dL, p<0.005). Using logistic regression analysis, CAOD (OR=23.0), NSAID use (OR=12.5), and lower serum albumin levels (OR=2.9) were identified as independent risk factors for GIB (p<0.05). Conclusions: Careful attention must be paid to ESRD patients with CAOD, taking NSAIDs, or with low serum albumin levels in view of GIB.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Dong Ki(김동기)
Kim, Seung Jun(김승준)
Moon, Sung Jin(문성진)
Moon, Ji Ae(문지애)
Park, Sun Young(박선영)
Oh, Hyung Jung(오형중)
Yoo, Dong Eun(유동은)
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Lee, Tae Hee(이태희)
Lee, Han Sung(이한성)
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
Han, Dae Suk(한대석)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97651
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