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국내 HIV 감염자에 있어서 Highly Active Antiretroviral Therapy (HAART)의 치료효과 및 영향분석

Other Titles
 Therapeutic Response of HAART and Analysis of Related Factors in Korean HIV-infected Persons 
 김영근  ;  김명수  ;  구남수  ;  김준형  ;  김준명  ;  송영구  ;  최준용  ;  박윤선  ;  김연아  ;  신소연 
 INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.39(3) : 142-150, 2007 
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Background:Recently, 2.1 persons per day are reported to be HIV infected and totally more than 4,500 HIV infected persons have been officially reported until 2006 in Korea. We started highly active antiretroviral therapy (HAART) for HIV patients from 1997. Data on the efficacy of antiretroviral therapy are limited in Korea. Materials and Methods:HIV infected patients treated with HAART for more than 1 year were included. We studied the therapeutic response of antiretroviral therapy in patients with AIDS and without previous antiretroviral therapy who were treated until Dec 2005 in Severance hospital. Results:More than 450 were diagnosed as HIV infected in Severance hospital. Among these HIV infected patients, 141 patients including 14 females were included. 121 of the 141 patients (85.8%) were treated with PI based regimen, and 20(14.2%) were treated with NNRTI based regimen. The initial mean CD4 T cell count was 207/mm3 (IQR 73-299) and the mean HIV RNA level was 70,800 copies/mL. After 6 months of HAART, 103 patients (73%) had fewer than 400 copies of HIV RNA copies/mL. After 12 months of HAART, 90 patients (63.8%) had fewer than 50 copies of HIV RNA copies/mL. The mean increase in the CD4 T cell count from baseline to 12 months was 143 cells/mm3. After 12 months, 96 patients (68.1%) had increased more than 100 cells/mm3. Conclusion:This report the therapeutic response of HAART in Korea which the prevalence of HIV infection is now increasing. Overall, the outcomes are similar to those in other developed countries. Further large scale prospective cohort study is needed.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Myoung Soo(김명수)
Kim, Yeon A(김연아)
Kim, June Myung(김준명)
Kim, Joon Hyung(김준형)
Park, Yoon Seon(박윤선)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Shin, So Youn(신소연)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
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